| 1 | Sat 24 Jan | 4 3-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg | German Bundesliga |
| 2 | Sat 31 Jan | 4 2-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 3 | Sat 7 Feb | 42-0 v FC AugsburgMainz 05 2-0 FC Augsburg | German Bundesliga |
| 4 | Fri 13 Feb | 4 0-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 | German Bundesliga |
| 5 | Fri 20 Feb | 41-1 v Hamburger SVMainz 05 1-1 Hamburger SV | German Bundesliga |
| 6 | Sat 28 Feb | 4 1-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 7 | Sat 7 Mar | 42-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart | German Bundesliga |
| 8 | Thu 12 Mar | 4 0-0 v Sigma OlomoucSigma Olomouc 0-0 Mainz 05 | UEFA Europa Conference League Round of 16 |
| 9 | Sun 15 Mar | 42-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
| 10 | Thu 19 Mar | 42-0 v Sigma OlomoucMainz 05 2-0 Sigma Olomouc | UEFA Europa Conference League Round of 16 |
| 11 | Sun 22 Mar | 42-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt | German Bundesliga |
| 12 | Sat 4 Apr | 42-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 13 | Thu 9 Apr | 4 2-0 v StrasbourgMainz 05 2-0 Strasbourg | UEFA Europa Conference League Quarter Final |
| 14 | Sun 12 Apr | 40-1 v SC FreiburgMainz 05 0-1 SC Freiburg | German Bundesliga |
| 15 | Thu 16 Apr | 40-4 v StrasbourgStrasbourg 4-0 Mainz 05 | UEFA Europa Conference League Quarter Final |
| 16 | Sun 19 Apr | 41-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Mainz 05 | German Bundesliga |
| 17 | Sat 25 Apr | 43-4 v Bayern MunichMainz 05 3-4 Bayern Munich | German Bundesliga |
| 18 | Sun 3 May | 42-1 v FC St PauliFC St Pauli 1-2 Mainz 05 | German Bundesliga |
| 19 | Sun 10 May | 41-3 v Union BerlinMainz 05 1-3 Union Berlin | German Bundesliga |
| 20 | Sat 16 May | 42-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 | German Bundesliga |
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