| 1 | Sat 31 Aug | 30 3-3 v VfB StuttgartVfB Stuttgart 3-3 Mainz 05 | German Bundesliga |
| 2 | Sun 15 Sep | 301-2 v Werder BremenMainz 05 1-2 Werder Bremen | German Bundesliga |
| 3 | Fri 20 Sep | 30 3-2 v FC AugsburgFC Augsburg 2-3 Mainz 05 | German Bundesliga |
| 4 | Sat 28 Sep | 300-2 v 1 FC HeidenheimMainz 05 0-2 1 FC Heidenheim | German Bundesliga |
| 5 | Sat 19 Oct | 300-2 v RB LeipzigMainz 05 0-2 RB Leipzig | German Bundesliga |
| 6 | Fri 25 Oct | 30 1-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 7 | Sun 3 Nov | 300-0 v SC FreiburgSC Freiburg 0-0 Mainz 05 | German Bundesliga |
| 8 | Sat 9 Nov | 303-1 v Borussia DortmundMainz 05 3-1 Borussia Dortmund | German Bundesliga |
| 9 | Sun 24 Nov | 303-0 v Holstein KielHolstein Kiel 0-3 Mainz 05 | German Bundesliga |
| 10 | Sun 1 Dec | 302-0 v 1899 HoffenheimMainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 11 | Sun 8 Dec | 303-4 v VfL WolfsburgVfL Wolfsburg 4-3 Mainz 05 | German Bundesliga |
| 12 | Sat 21 Dec | 303-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Mainz 05 | German Bundesliga |
| 13 | Sat 11 Jan | 302-0 v VfL BochumMainz 05 2-0 VfL Bochum | German Bundesliga |
| 14 | Tue 14 Jan | 300-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 15 | Sun 19 Jan | 301-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 Mainz 05 | German Bundesliga |
| 16 | Sat 25 Jan | 302-0 v VfB StuttgartMainz 05 2-0 VfB Stuttgart | German Bundesliga |
| 17 | Fri 31 Jan | 300-1 v Werder BremenWerder Bremen 1-0 Mainz 05 | German Bundesliga |
| 18 | Sat 8 Feb | 300-0 v FC AugsburgMainz 05 0-0 FC Augsburg | German Bundesliga |
| 19 | Sun 16 Feb | 302-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 | German Bundesliga |
| 20 | Sat 22 Feb | 302-0 v FC St PauliMainz 05 2-0 FC St Pauli | German Bundesliga |
| 21 | Fri 7 Mar | 303-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 Mainz 05 | German Bundesliga |
| 22 | Sun 30 Mar | 301-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 23 | Sat 19 Apr | 302-2 v VfL WolfsburgMainz 05 2-2 VfL Wolfsburg | German Bundesliga |
| 24 | Sat 26 Apr | 300-3 v Bayern MunichBayern Munich 3-0 Mainz 05 | German Bundesliga |
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