| 1 | Thu 21 Aug | 21-2 v RosenborgRosenborg 2-1 Mainz 05 | UEFA Europa Conference League |
| 2 | Sun 24 Aug | 20-1 v 1 FC KölnMainz 05 0-1 1 FC Köln | German Bundesliga |
| 3 | Thu 28 Aug | 24-1 v RosenborgMainz 05 4-1 Rosenborg | UEFA Europa Conference League |
| 4 | Sun 31 Aug | 21-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 | German Bundesliga |
| 5 | Sat 13 Sep | 20-1 v RB LeipzigMainz 05 0-1 RB Leipzig | German Bundesliga |
| 6 | Sat 20 Sep | 24-1 v FC AugsburgFC Augsburg 1-4 Mainz 05 | German Bundesliga |
| 7 | Sat 27 Sep | 20-2 v Borussia DortmundMainz 05 0-2 Borussia Dortmund | German Bundesliga |
| 8 | Thu 2 Oct | 21-0 v Omonia NicosiaOmonia Nicosia 0-1 Mainz 05 | UEFA Europa Conference League Matchday 1 |
| 9 | Sun 5 Oct | 20-4 v Hamburger SVHamburger SV 4-0 Mainz 05 | German Bundesliga |
| 10 | Sat 18 Oct | 23-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 11 | Thu 23 Oct | 21-0 v Zrinjski MostarMainz 05 1-0 Zrinjski Mostar | UEFA Europa Conference League Matchday 2 |
| 12 | Sun 26 Oct | 2 1-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 13 | Sat 1 Nov | 21-1 v Werder BremenMainz 05 1-1 Werder Bremen | German Bundesliga |
| 14 | Thu 6 Nov | 22-1 v FiorentinaMainz 05 2-1 Fiorentina | UEFA Europa Conference League Matchday 3 |
| 15 | Sun 9 Nov | 2 0-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 | German Bundesliga |
| 16 | Fri 21 Nov | 2 1-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim | German Bundesliga |
| 17 | Sun 30 Nov | 20-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 | German Bundesliga |
| 18 | Fri 5 Dec | 20-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach | German Bundesliga |
| 19 | Sat 24 Jan | 23-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg | German Bundesliga |
| 20 | Sat 31 Jan | 22-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 21 | Sat 7 Feb | 22-0 v FC AugsburgMainz 05 2-0 FC Augsburg | German Bundesliga |
| 22 | Fri 13 Feb | 20-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 | German Bundesliga |
| 23 | Fri 20 Feb | 21-1 v Hamburger SVMainz 05 1-1 Hamburger SV | German Bundesliga |
| 24 | Sat 28 Feb | 21-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 25 | Sat 7 Mar | 22-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart | German Bundesliga |
| 26 | Thu 12 Mar | 20-0 v Sigma OlomoucSigma Olomouc 0-0 Mainz 05 | UEFA Europa Conference League Round of 16 |
| 27 | Sun 15 Mar | 22-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
| 28 | Thu 19 Mar | 22-0 v Sigma OlomoucMainz 05 2-0 Sigma Olomouc | UEFA Europa Conference League Round of 16 |
| 29 | Sun 22 Mar | 2 2-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt | German Bundesliga |
| 30 | Sat 4 Apr | 22-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 31 | Thu 9 Apr | 22-0 v StrasbourgMainz 05 2-0 Strasbourg | UEFA Europa Conference League Quarter Final |
| 32 | Sun 12 Apr | 20-1 v SC FreiburgMainz 05 0-1 SC Freiburg | German Bundesliga |
| 33 | Thu 16 Apr | 20-4 v StrasbourgStrasbourg 4-0 Mainz 05 | UEFA Europa Conference League Quarter Final |
| 34 | Sun 19 Apr | 21-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Mainz 05 | German Bundesliga |
| 35 | Sat 25 Apr | 23-4 v Bayern MunichMainz 05 3-4 Bayern Munich | German Bundesliga |
Football Web Pages