| 1 | Thu 28 Aug | 224-1 v RosenborgMainz 05 4-1 Rosenborg | UEFA Europa Conference League |
| 2 | Sun 31 Aug | 221-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 | German Bundesliga |
| 3 | Sat 13 Sep | 220-1 v RB LeipzigMainz 05 0-1 RB Leipzig | German Bundesliga |
| 4 | Sat 20 Sep | 224-1 v FC AugsburgFC Augsburg 1-4 Mainz 05 | German Bundesliga |
| 5 | Thu 2 Oct | 221-0 v Omonia NicosiaOmonia Nicosia 0-1 Mainz 05 | UEFA Europa Conference League Matchday 1 |
| 6 | Sun 5 Oct | 220-4 v Hamburger SVHamburger SV 4-0 Mainz 05 | German Bundesliga |
| 7 | Sat 18 Oct | 223-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 8 | Sun 26 Oct | 221-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 9 | Sat 1 Nov | 22 1-1 v Werder BremenMainz 05 1-1 Werder Bremen | German Bundesliga |
| 10 | Sun 9 Nov | 220-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 | German Bundesliga |
| 11 | Thu 27 Nov | 220-1 v CS Universitatea CraiovaCS Universitatea Craiova 1-0 Mainz 05 | UEFA Europa Conference League Matchday 4 |
| 12 | Fri 5 Dec | 22 0-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach | German Bundesliga |
| 13 | Thu 11 Dec | 22 1-1 v Lech PoznańLech Poznań 1-1 Mainz 05 | UEFA Europa Conference League Matchday 5 |
| 14 | Sun 14 Dec | 222-2 v Bayern MunichBayern Munich 2-2 Mainz 05 | German Bundesliga |
| 15 | Sun 21 Dec | 220-0 v FC St PauliMainz 05 0-0 FC St Pauli | German Bundesliga |
| 16 | Sat 10 Jan | 222-2 v Union BerlinUnion Berlin 2-2 Mainz 05 | German Bundesliga |
| 17 | Tue 13 Jan | 222-1 v 1 FC HeidenheimMainz 05 2-1 1 FC Heidenheim | German Bundesliga |
| 18 | Fri 20 Feb | 221-1 v Hamburger SVMainz 05 1-1 Hamburger SV | German Bundesliga |
| 19 | Sat 7 Mar | 222-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart | German Bundesliga |
| 20 | Sun 15 Mar | 222-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
| 21 | Thu 19 Mar | 222-0 v Sigma OlomoucMainz 05 2-0 Sigma Olomouc | UEFA Europa Conference League Round of 16 |
| 22 | Sun 22 Mar | 222-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt | German Bundesliga |
| 23 | Sat 4 Apr | 222-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 24 | Thu 9 Apr | 222-0 v StrasbourgMainz 05 2-0 Strasbourg | UEFA Europa Conference League Quarter Final |
| 25 | Sun 12 Apr | 22 0-1 v SC FreiburgMainz 05 0-1 SC Freiburg | German Bundesliga |
| 26 | Thu 16 Apr | 22 0-4 v StrasbourgStrasbourg 4-0 Mainz 05 | UEFA Europa Conference League Quarter Final |
| 27 | Sun 19 Apr | 221-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Mainz 05 | German Bundesliga |
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