| 1 | Sat 24 Aug | 441-1 v 1 FC Union BerlinMainz 05 1-1 1 FC Union Berlin | German Bundesliga |
| 2 | Sat 28 Sep | 440-2 v 1 FC HeidenheimMainz 05 0-2 1 FC Heidenheim | German Bundesliga |
| 3 | Sat 5 Oct | 443-0 v FC St PauliFC St Pauli 0-3 Mainz 05 | German Bundesliga |
| 4 | Sat 19 Oct | 440-2 v RB LeipzigMainz 05 0-2 RB Leipzig | German Bundesliga |
| 5 | Fri 25 Oct | 441-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 6 | Sat 11 Jan | 442-0 v VfL BochumMainz 05 2-0 VfL Bochum | German Bundesliga |
| 7 | Tue 14 Jan | 440-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 8 | Sun 19 Jan | 441-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 Mainz 05 | German Bundesliga |
| 9 | Sat 25 Jan | 44 2-0 v VfB StuttgartMainz 05 2-0 VfB Stuttgart | German Bundesliga |
| 10 | Fri 31 Jan | 440-1 v Werder BremenWerder Bremen 1-0 Mainz 05 | German Bundesliga |
| 11 | Sat 8 Feb | 44 0-0 v FC AugsburgMainz 05 0-0 FC Augsburg | German Bundesliga |
| 12 | Sun 16 Feb | 442-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 | German Bundesliga |
| 13 | Sat 22 Feb | 442-0 v FC St PauliMainz 05 2-0 FC St Pauli | German Bundesliga |
| 14 | Sat 1 Mar | 442-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 15 | Fri 7 Mar | 443-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 Mainz 05 | German Bundesliga |
| 16 | Sun 30 Mar | 441-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 17 | Sat 5 Apr | 441-1 v Holstein KielMainz 05 1-1 Holstein Kiel | German Bundesliga |
| 18 | Sat 12 Apr | 440-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 19 | Sat 19 Apr | 442-2 v VfL WolfsburgMainz 05 2-2 VfL Wolfsburg | German Bundesliga |
| 20 | Sat 26 Apr | 440-3 v Bayern MunichBayern Munich 3-0 Mainz 05 | German Bundesliga |
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