| 1 | Thu 2 Oct | 481-0 v Omonia NicosiaOmonia Nicosia 0-1 Mainz 05 | UEFA Europa Conference League Matchday 1 |
| 2 | Thu 23 Oct | 481-0 v Zrinjski MostarMainz 05 1-0 Zrinjski Mostar | UEFA Europa Conference League Matchday 2 |
| 3 | Thu 6 Nov | 482-1 v FiorentinaMainz 05 2-1 Fiorentina | UEFA Europa Conference League Matchday 3 |
| 4 | Thu 27 Nov | 480-1 v CS Universitatea CraiovaCS Universitatea Craiova 1-0 Mainz 05 | UEFA Europa Conference League Matchday 4 |
| 5 | Sun 30 Nov | 480-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 | German Bundesliga |
| 6 | Sun 14 Dec | 48 2-2 v Bayern MunichBayern Munich 2-2 Mainz 05 | German Bundesliga |
| 7 | Thu 18 Dec | 482-0 v SamsunsporMainz 05 2-0 Samsunspor | UEFA Europa Conference League Matchday 6 |
| 8 | Sun 21 Dec | 480-0 v FC St PauliMainz 05 0-0 FC St Pauli | German Bundesliga |
| 9 | Tue 13 Jan | 482-1 v 1 FC HeidenheimMainz 05 2-1 1 FC Heidenheim | German Bundesliga |
| 10 | Sat 17 Jan | 481-2 v 1 FC Köln1 FC Köln 2-1 Mainz 05 | German Bundesliga |
| 11 | Sat 31 Jan | 48 2-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 12 | Sat 7 Feb | 482-0 v FC AugsburgMainz 05 2-0 FC Augsburg | German Bundesliga |
| 13 | Fri 13 Feb | 480-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 | German Bundesliga |
| 14 | Fri 20 Feb | 48 1-1 v Hamburger SVMainz 05 1-1 Hamburger SV | German Bundesliga |
| 15 | Sat 28 Feb | 481-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 16 | Thu 12 Mar | 480-0 v Sigma OlomoucSigma Olomouc 0-0 Mainz 05 | UEFA Europa Conference League Round of 16 |
| 17 | Sun 15 Mar | 482-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
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