| 1 | Thu 21 Aug | 31 1-2 v RosenborgRosenborg 2-1 Mainz 05 | UEFA Europa Conference League |
| 2 | Sun 24 Aug | 310-1 v 1 FC KölnMainz 05 0-1 1 FC Köln | German Bundesliga |
| 3 | Thu 28 Aug | 314-1 v RosenborgMainz 05 4-1 Rosenborg | UEFA Europa Conference League |
| 4 | Sun 31 Aug | 311-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 | German Bundesliga |
| 5 | Sat 13 Sep | 310-1 v RB LeipzigMainz 05 0-1 RB Leipzig | German Bundesliga |
| 6 | Sat 20 Sep | 31 4-1 v FC AugsburgFC Augsburg 1-4 Mainz 05 | German Bundesliga |
| 7 | Sun 5 Oct | 31 0-4 v Hamburger SVHamburger SV 4-0 Mainz 05 | German Bundesliga |
| 8 | Sat 18 Oct | 31 3-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 9 | Thu 23 Oct | 311-0 v Zrinjski MostarMainz 05 1-0 Zrinjski Mostar | UEFA Europa Conference League Matchday 2 |
| 10 | Sun 26 Oct | 31 1-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 11 | Sat 1 Nov | 311-1 v Werder BremenMainz 05 1-1 Werder Bremen | German Bundesliga |
| 12 | Thu 6 Nov | 312-1 v FiorentinaMainz 05 2-1 Fiorentina | UEFA Europa Conference League Matchday 3 |
| 13 | Sun 9 Nov | 310-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 | German Bundesliga |
| 14 | Fri 21 Nov | 31 1-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim | German Bundesliga |
| 15 | Thu 27 Nov | 310-1 v CS Universitatea CraiovaCS Universitatea Craiova 1-0 Mainz 05 | UEFA Europa Conference League Matchday 4 |
| 16 | Thu 11 Dec | 311-1 v Lech PoznańLech Poznań 1-1 Mainz 05 | UEFA Europa Conference League Matchday 5 |
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