| 1 | Fri 5 Dec | 330-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach | German Bundesliga |
| 2 | Thu 11 Dec | 331-1 v Lech PoznańLech Poznań 1-1 Mainz 05 | UEFA Europa Conference League Matchday 5 |
| 3 | Sun 14 Dec | 332-2 v Bayern MunichBayern Munich 2-2 Mainz 05 | German Bundesliga |
| 4 | Thu 18 Dec | 332-0 v SamsunsporMainz 05 2-0 Samsunspor | UEFA Europa Conference League Matchday 6 |
| 5 | Sun 21 Dec | 330-0 v FC St PauliMainz 05 0-0 FC St Pauli | German Bundesliga |
| 6 | Sat 10 Jan | 332-2 v Union BerlinUnion Berlin 2-2 Mainz 05 | German Bundesliga |
| 7 | Tue 13 Jan | 332-1 v 1 FC HeidenheimMainz 05 2-1 1 FC Heidenheim | German Bundesliga |
| 8 | Sat 17 Jan | 33 1-2 v 1 FC Köln1 FC Köln 2-1 Mainz 05 | German Bundesliga |
| 9 | Sat 24 Jan | 333-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg | German Bundesliga |
| 10 | Sat 31 Jan | 332-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 11 | Sat 7 Feb | 332-0 v FC AugsburgMainz 05 2-0 FC Augsburg | German Bundesliga |
| 12 | Fri 13 Feb | 330-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 | German Bundesliga |
| 13 | Fri 20 Feb | 331-1 v Hamburger SVMainz 05 1-1 Hamburger SV | German Bundesliga |
| 14 | Sat 28 Feb | 331-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 | German Bundesliga |
| 15 | Sat 7 Mar | 332-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart | German Bundesliga |
| 16 | Thu 12 Mar | 330-0 v Sigma OlomoucSigma Olomouc 0-0 Mainz 05 | UEFA Europa Conference League Round of 16 |
| 17 | Sun 15 Mar | 332-0 v Werder BremenWerder Bremen 0-2 Mainz 05 | German Bundesliga |
| 18 | Thu 19 Mar | 332-0 v Sigma OlomoucMainz 05 2-0 Sigma Olomouc | UEFA Europa Conference League Round of 16 |
| 19 | Sun 22 Mar | 332-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt | German Bundesliga |
| 20 | Sat 4 Apr | 332-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 | German Bundesliga |
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