| 1 | Thu 21 Aug | 171-2 v RosenborgRosenborg 2-1 Mainz 05 | UEFA Europa Conference League |
| 2 | Sun 24 Aug | 170-1 v 1 FC KölnMainz 05 0-1 1 FC Köln | German Bundesliga |
| 3 | Thu 2 Oct | 171-0 v Omonia NicosiaOmonia Nicosia 0-1 Mainz 05 | UEFA Europa Conference League Matchday 1 |
| 4 | Sun 5 Oct | 170-4 v Hamburger SVHamburger SV 4-0 Mainz 05 | German Bundesliga |
| 5 | Sat 18 Oct | 173-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 6 | Sun 26 Oct | 171-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 7 | Sat 1 Nov | 171-1 v Werder BremenMainz 05 1-1 Werder Bremen | German Bundesliga |
| 8 | Thu 6 Nov | 172-1 v FiorentinaMainz 05 2-1 Fiorentina | UEFA Europa Conference League Matchday 3 |
| 9 | Sun 9 Nov | 170-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 | German Bundesliga |
| 10 | Fri 21 Nov | 171-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim | German Bundesliga |
| 11 | Sun 30 Nov | 170-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 | German Bundesliga |
| 12 | Thu 11 Dec | 171-1 v Lech PoznańLech Poznań 1-1 Mainz 05 | UEFA Europa Conference League Matchday 5 |
| 13 | Sun 14 Dec | 172-2 v Bayern MunichBayern Munich 2-2 Mainz 05 | German Bundesliga |
| 14 | Thu 18 Dec | 172-0 v SamsunsporMainz 05 2-0 Samsunspor | UEFA Europa Conference League Matchday 6 |
| 15 | Sun 21 Dec | 170-0 v FC St PauliMainz 05 0-0 FC St Pauli | German Bundesliga |
| 16 | Sat 10 Jan | 172-2 v Union BerlinUnion Berlin 2-2 Mainz 05 | German Bundesliga |
| 17 | Sat 24 Jan | 173-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg | German Bundesliga |
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