| 1 | Thu 21 Aug | 251-2 v RosenborgRosenborg 2-1 Mainz 05 | UEFA Europa Conference League |
| 2 | Sun 24 Aug | 250-1 v 1 FC KölnMainz 05 0-1 1 FC Köln | German Bundesliga |
| 3 | Sun 31 Aug | 25 1-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 | German Bundesliga |
| 4 | Sat 13 Sep | 250-1 v RB LeipzigMainz 05 0-1 RB Leipzig | German Bundesliga |
| 5 | Sat 20 Sep | 254-1 v FC AugsburgFC Augsburg 1-4 Mainz 05 | German Bundesliga |
| 6 | Sat 27 Sep | 250-2 v Borussia DortmundMainz 05 0-2 Borussia Dortmund | German Bundesliga |
| 7 | Thu 2 Oct | 251-0 v Omonia NicosiaOmonia Nicosia 0-1 Mainz 05 | UEFA Europa Conference League Matchday 1 |
| 8 | Sun 5 Oct | 250-4 v Hamburger SVHamburger SV 4-0 Mainz 05 | German Bundesliga |
| 9 | Sat 18 Oct | 25 3-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen | German Bundesliga |
| 10 | Thu 23 Oct | 25 1-0 v Zrinjski MostarMainz 05 1-0 Zrinjski Mostar | UEFA Europa Conference League Matchday 2 |
| 11 | Sun 26 Oct | 251-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 12 | Sat 1 Nov | 251-1 v Werder BremenMainz 05 1-1 Werder Bremen | German Bundesliga |
| 13 | Fri 21 Nov | 251-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim | German Bundesliga |
| 14 | Thu 27 Nov | 250-1 v CS Universitatea CraiovaCS Universitatea Craiova 1-0 Mainz 05 | UEFA Europa Conference League Matchday 4 |
| 15 | Sun 30 Nov | 250-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 | German Bundesliga |
| 16 | Fri 5 Dec | 25 0-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach | German Bundesliga |
| 17 | Thu 11 Dec | 251-1 v Lech PoznańLech Poznań 1-1 Mainz 05 | UEFA Europa Conference League Matchday 5 |
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