| 1 | Sat 31 Oct 2020 | 171-3 v FC AugsburgFC Augsburg 3-1 Mainz 05 | German Bundesliga |
| 2 | Sun 29 Nov 2020 | 171-1 v 1899 HoffenheimMainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 5 Dec 2020 | 171-2 v Arminia BielefeldArminia Bielefeld 2-1 Mainz 05 | German Bundesliga |
| 4 | Sat 12 Dec 2020 | 17 0-1 v 1. FC KölnMainz 05 0-1 1. FC Köln | German Bundesliga |
| 5 | Tue 15 Dec 2020 | 17 0-0 v Hertha BerlinHertha Berlin 0-0 Mainz 05 | German Bundesliga |
| 6 | Sat 19 Dec 2020 | 170-1 v Werder BremenMainz 05 0-1 Werder Bremen | German Bundesliga |
| 7 | Sun 3 Jan 2021 | 172-5 v Bayern MunichBayern Munich 5-2 Mainz 05 | German Bundesliga |
| 8 | Sat 9 Jan 2021 | 170-2 v Eintracht FrankfurtMainz 05 0-2 Eintracht Frankfurt | German Bundesliga |
| 9 | Sat 16 Jan 2021 | 171-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 10 | Sat 23 Jan 2021 | 173-2 v RB LeipzigMainz 05 3-2 RB Leipzig | German Bundesliga |
| 11 | Fri 29 Jan 2021 | 170-2 v VfB StuttgartVfB Stuttgart 2-0 Mainz 05 | German Bundesliga |
| 12 | Sat 13 Feb 2021 | 17 2-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 Mainz 05 | German Bundesliga |
| 13 | Sat 20 Feb 2021 | 172-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Mainz 05 | German Bundesliga |
| 14 | Sun 28 Feb 2021 | 170-1 v FC AugsburgMainz 05 0-1 FC Augsburg | German Bundesliga |
| 15 | Fri 5 Mar 2021 | 170-0 v FC Schalke 04FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 16 | Sat 13 Mar 2021 | 171-0 v SC FreiburgMainz 05 1-0 SC Freiburg | German Bundesliga |
| 17 | Sun 21 Mar 2021 | 172-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 18 | Wed 21 Apr 2021 | 171-0 v Werder BremenWerder Bremen 0-1 Mainz 05 | German Bundesliga |
| 19 | Sun 16 May 2021 | 171-3 v Borussia DortmundMainz 05 1-3 Borussia Dortmund | German Bundesliga |
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