| 1 | Sun 20 Sep 2020 | 6 1-3 v RB LeipzigRB Leipzig 3-1 Mainz 05 | German Bundesliga |
| 2 | Sat 26 Sep 2020 | 61-4 v VfB StuttgartMainz 05 1-4 VfB Stuttgart | German Bundesliga |
| 3 | Fri 2 Oct 2020 | 6 0-4 v 1. FC Union Berlin1. FC Union Berlin 4-0 Mainz 05 | German Bundesliga |
| 4 | Sat 17 Oct 2020 | 6 0-1 v Bayer 04 LeverkusenMainz 05 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Sat 24 Oct 2020 | 6 2-3 v Borussia MönchengladbachMainz 05 2-3 Borussia Mönchengladbach | German Bundesliga |
| 6 | Sat 31 Oct 2020 | 61-3 v FC AugsburgFC Augsburg 3-1 Mainz 05 | German Bundesliga |
| 7 | Sat 7 Nov 2020 | 6 2-2 v FC Schalke 04Mainz 05 2-2 FC Schalke 04 | German Bundesliga |
| 8 | Sat 12 Dec 2020 | 6 0-1 v 1. FC KölnMainz 05 0-1 1. FC Köln | German Bundesliga |
| 9 | Tue 15 Dec 2020 | 60-0 v Hertha BerlinHertha Berlin 0-0 Mainz 05 | German Bundesliga |
| 10 | Sat 19 Dec 2020 | 60-1 v Werder BremenMainz 05 0-1 Werder Bremen | German Bundesliga |
| 11 | Sun 3 Jan 2021 | 62-5 v Bayern MunichBayern Munich 5-2 Mainz 05 | German Bundesliga |
| 12 | Sat 9 Jan 2021 | 60-2 v Eintracht FrankfurtMainz 05 0-2 Eintracht Frankfurt | German Bundesliga |
| 13 | Sat 16 Jan 2021 | 61-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 14 | Tue 19 Jan 2021 | 60-2 v VfL WolfsburgMainz 05 0-2 VfL Wolfsburg | German Bundesliga |
| 15 | Sat 23 Jan 2021 | 63-2 v RB LeipzigMainz 05 3-2 RB Leipzig | German Bundesliga |
| 16 | Fri 29 Jan 2021 | 60-2 v VfB StuttgartVfB Stuttgart 2-0 Mainz 05 | German Bundesliga |
| 17 | Sat 6 Feb 2021 | 61-0 v 1. FC Union BerlinMainz 05 1-0 1. FC Union Berlin | German Bundesliga |
| 18 | Sat 13 Feb 2021 | 62-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 Mainz 05 | German Bundesliga |
| 19 | Sat 20 Feb 2021 | 62-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Mainz 05 | German Bundesliga |
| 20 | Sun 28 Feb 2021 | 6 0-1 v FC AugsburgMainz 05 0-1 FC Augsburg | German Bundesliga |
| 21 | Fri 5 Mar 2021 | 60-0 v FC Schalke 04FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 22 | Sat 3 Apr 2021 | 6 1-1 v Arminia BielefeldMainz 05 1-1 Arminia Bielefeld | German Bundesliga |
| 23 | Sun 11 Apr 2021 | 63-2 v 1. FC Köln1. FC Köln 2-3 Mainz 05 | German Bundesliga |
| 24 | Wed 21 Apr 2021 | 61-0 v Werder BremenWerder Bremen 0-1 Mainz 05 | German Bundesliga |
| 25 | Sat 24 Apr 2021 | 62-1 v Bayern MunichMainz 05 2-1 Bayern Munich | German Bundesliga |
| 26 | Mon 3 May 2021 | 61-1 v Hertha BerlinMainz 05 1-1 Hertha Berlin | German Bundesliga |
| 27 | Sun 9 May 2021 | 61-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Mainz 05 | German Bundesliga |
| 28 | Sun 16 May 2021 | 61-3 v Borussia DortmundMainz 05 1-3 Borussia Dortmund | German Bundesliga |
| 29 | Sat 22 May 2021 | 63-2 v VfL WolfsburgVfL Wolfsburg 2-3 Mainz 05 | German Bundesliga |
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