| 1 | Fri 10 Aug 2012 | 51-2 v Hereford UnitedHereford United 2-1 Macclesfield Town | Blue Square Bet Premier |
| 2 | Tue 14 Aug 2012 | 52-0 v WrexhamMacclesfield Town 2-0 Wrexham | Blue Square Bet Premier |
| 3 | Sat 18 Aug 2012 | 52-0 v DartfordMacclesfield Town 2-0 Dartford | Blue Square Bet Premier |
| 4 | Sat 25 Aug 2012 | 53-2 v Lincoln CityLincoln City 2-3 Macclesfield Town | Blue Square Bet Premier |
| 5 | Mon 27 Aug 2012 | 52-0 v BarrowMacclesfield Town 2-0 Barrow | Blue Square Bet Premier |
| 6 | Sat 1 Sep 2012 | 51-4 v Luton TownLuton Town 4-1 Macclesfield Town | Blue Square Bet Premier |
| 7 | Tue 4 Sep 2012 | 54-3 v Stockport CountyStockport County 3-4 Macclesfield Town | Blue Square Bet Premier |
| 8 | Sat 8 Sep 2012 | 52-1 v Braintree TownMacclesfield Town 2-1 Braintree Town | Blue Square Bet Premier |
| 9 | Sat 22 Sep 2012 | 51-2 v Forest Green RoversMacclesfield Town 1-2 Forest Green Rovers | Blue Square Bet Premier |
| 10 | Sat 29 Sep 2012 | 50-3 v Kidderminster HarriersKidderminster Harriers 3-0 Macclesfield Town | Blue Square Bet Premier |
| 11 | Sat 6 Oct 2012 | 51-2 v Alfreton TownMacclesfield Town 1-2 Alfreton Town | Blue Square Bet Premier |
| 12 | Tue 9 Oct 2012 | 52-2 v GatesheadGateshead 2-2 Macclesfield Town | Blue Square Bet Premier |
| 13 | Sat 13 Oct 2012 | 51-1 v Newport CountyMacclesfield Town 1-1 Newport County | Blue Square Bet Premier |
| 14 | Tue 4 Dec 2012 | 53-2 v HydeMacclesfield Town 3-2 Hyde | Blue Square Bet Premier |
| 15 | Sat 8 Dec 2012 | 51-1 v Forest Green RoversForest Green Rovers 1-1 Macclesfield Town | Blue Square Bet Premier |
| 16 | Sat 15 Dec 2012 | 50-0 v Nuneaton TownMacclesfield Town 0-0 Nuneaton Town | Blue Square Bet Premier |
| 17 | Tue 18 Dec 2012 | 51-1 v BarrowBarrow 1-1 Macclesfield Town | FA Cup with Budweiser Second Round |
| 18 | Wed 26 Dec 2012 | 52-3 v SouthportSouthport 3-2 Macclesfield Town | Blue Square Bet Premier |
| 19 | Sat 29 Dec 2012 | 54-1 v BarrowMacclesfield Town 4-1 Barrow | FA Cup with Budweiser Second Round Replay |
| 20 | Tue 1 Jan 2013 | 52-2 v SouthportMacclesfield Town 2-2 Southport | Blue Square Bet Premier |
| 21 | Sat 5 Jan 2013 | 52-1 v Cardiff CityMacclesfield Town 2-1 Cardiff City | FA Cup with Budweiser Third Round |
| 22 | Tue 8 Jan 2013 | 53-0 v Braintree TownBraintree Town 0-3 Macclesfield Town | Blue Square Bet Premier |
| 23 | Tue 15 Jan 2013 | 50-2 v DartfordDartford 2-0 Macclesfield Town | Blue Square Bet Premier |
| 24 | Sat 19 Jan 2013 | 51-0 v Kidderminster HarriersMacclesfield Town 1-0 Kidderminster Harriers | Blue Square Bet Premier |
| 25 | Sat 26 Jan 2013 | 50-1 v Wigan AthleticMacclesfield Town 0-1 Wigan Athletic | FA Cup with Budweiser Fourth Round |
| 26 | Fri 1 Feb 2013 | 54-0 v Ebbsfleet UnitedEbbsfleet United 0-4 Macclesfield Town | Blue Square Bet Premier |
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