| 1 | Sat 8 Aug 2015 | 41-1 v Accrington StanleyAccrington Stanley 1-1 Luton Town | Sky Bet League Two |
| 2 | Sat 15 Aug 2015 | 42-2 v Oxford UnitedLuton Town 2-2 Oxford United | Sky Bet League Two |
| 3 | Tue 18 Aug 2015 | 40-1 v Bristol RoversLuton Town 0-1 Bristol Rovers | Sky Bet League Two |
| 4 | Sat 22 Aug 2015 | 42-3 v Yeovil TownYeovil Town 3-2 Luton Town | Sky Bet League Two |
| 5 | Tue 25 Aug 2015 | 41-1 v Stoke CityLuton Town 1-1 Stoke City | Capital One Cup Second Round |
| 6 | Sat 29 Aug 2015 | 41-2 v PortsmouthLuton Town 1-2 Portsmouth | Sky Bet League Two |
| 7 | Tue 1 Sep 2015 | 42-1 v Leyton OrientLuton Town 2-1 Leyton Orient | Johnstone's Paint Trophy Southern Area First Round |
| 8 | Sat 5 Sep 2015 | 43-1 v Cambridge UnitedCambridge United 1-3 Luton Town | Sky Bet League Two |
| 9 | Sat 12 Sep 2015 | 42-3 v Notts CountyNotts County 3-2 Luton Town | Sky Bet League Two |
| 10 | Sat 19 Sep 2015 | 41-0 v Mansfield TownLuton Town 1-0 Mansfield Town | Sky Bet League Two |
| 11 | Sat 26 Sep 2015 | 42-0 v AFC WimbledonLuton Town 2-0 AFC Wimbledon | Sky Bet League Two |
| 12 | Tue 29 Sep 2015 | 43-1 v MorecambeMorecambe 1-3 Luton Town | Sky Bet League Two |
| 13 | Sat 3 Oct 2015 | 44-1 v Hartlepool UnitedHartlepool United 1-4 Luton Town | Sky Bet League Two |
| 14 | Sat 10 Oct 2015 | 41-1 v York CityLuton Town 1-1 York City | Sky Bet League Two |
| 15 | Sat 17 Oct 2015 | 41-2 v Crawley TownCrawley Town 2-1 Luton Town | Sky Bet League Two |
| 16 | Tue 20 Oct 2015 | 41-1 v Leyton OrientLuton Town 1-1 Leyton Orient | Sky Bet League Two |
| 17 | Sat 24 Oct 2015 | 41-2 v Plymouth ArgyleLuton Town 1-2 Plymouth Argyle | Sky Bet League Two |
| 18 | Sun 1 Nov 2015 | 42-0 v Dagenham & RedbridgeDagenham & Redbridge 0-2 Luton Town | Sky Bet League Two |
| 19 | Sat 7 Nov 2015 | 42-1 v Crawley TownCrawley Town 1-2 Luton Town | Emirates FA Cup First Round |
| 20 | Sat 14 Nov 2015 | 42-0 v BarnetLuton Town 2-0 Barnet | Sky Bet League Two |
| 21 | Sat 21 Nov 2015 | 40-0 v StevenageStevenage 0-0 Luton Town | Sky Bet League Two |
| 22 | Tue 24 Nov 2015 | 43-4 v Carlisle UnitedLuton Town 3-4 Carlisle United | Sky Bet League Two |
| 23 | Sat 28 Nov 2015 | 40-3 v Newport CountyNewport County 3-0 Luton Town | Sky Bet League Two |
| 24 | Sun 6 Dec 2015 | 40-2 v Peterborough UnitedPeterborough United 2-0 Luton Town | Emirates FA Cup Second Round |
| 25 | Sat 12 Dec 2015 | 43-4 v Northampton TownLuton Town 3-4 Northampton Town | Sky Bet League Two |
| 26 | Mon 28 Dec 2015 | 40-0 v PortsmouthPortsmouth 0-0 Luton Town | Sky Bet League Two |
| 27 | Sat 2 Jan 2016 | 40-2 v Bristol RoversBristol Rovers 2-0 Luton Town | Sky Bet League Two |
| 28 | Sat 16 Jan 2016 | 40-0 v Cambridge UnitedLuton Town 0-0 Cambridge United | Sky Bet League Two |
| 29 | Sat 23 Jan 2016 | 42-0 v Mansfield TownMansfield Town 0-2 Luton Town | Sky Bet League Two |
| 30 | Sat 30 Jan 2016 | 40-2 v Notts CountyLuton Town 0-2 Notts County | Sky Bet League Two |
| 31 | Sat 13 Feb 2016 | 41-4 v AFC WimbledonAFC Wimbledon 4-1 Luton Town | Sky Bet League Two |
| 32 | Sat 27 Feb 2016 | 43-2 v York CityYork City 2-3 Luton Town | Sky Bet League Two |
| 33 | Tue 1 Mar 2016 | 41-0 v MorecambeLuton Town 1-0 Morecambe | Sky Bet League Two |
| 34 | Sat 5 Mar 2016 | 41-0 v Leyton OrientLeyton Orient 0-1 Luton Town | Sky Bet League Two |
| 35 | Sat 12 Mar 2016 | 40-1 v Crawley TownLuton Town 0-1 Crawley Town | Sky Bet League Two |
| 36 | Sat 19 Mar 2016 | 41-0 v Plymouth ArgylePlymouth Argyle 0-1 Luton Town | Sky Bet League Two |
| 37 | Mon 28 Mar 2016 | 41-2 v BarnetBarnet 2-1 Luton Town | Sky Bet League Two |
| 38 | Sat 2 Apr 2016 | 40-1 v StevenageLuton Town 0-1 Stevenage | Sky Bet League Two |
| 39 | Sat 9 Apr 2016 | 40-2 v Accrington StanleyLuton Town 0-2 Accrington Stanley | Sky Bet League Two |
| 40 | Tue 12 Apr 2016 | 41-0 v Dagenham & RedbridgeLuton Town 1-0 Dagenham & Redbridge | Sky Bet League Two |
| 41 | Sat 30 Apr 2016 | 40-2 v Northampton TownNorthampton Town 2-0 Luton Town | Sky Bet League Two |
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