| 1 | Sat 31 Jul 2021 | 6 2-1 v CSKA MoscowCSKA Moscow 1-2 Lokomotiv Moscow | Russian Premier League |
| 2 | Fri 6 Aug 2021 | 6 1-1 v UfaUfa 1-1 Lokomotiv Moscow | Russian Premier League |
| 3 | Sun 22 Aug 2021 | 6 2-1 v FK KrasnodarLokomotiv Moscow 2-1 FK Krasnodar | Russian Premier League |
| 4 | Fri 27 Aug 2021 | 6 1-1 v Dinamo MoscowDinamo Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 5 | Thu 16 Sep 2021 | 61-1 v MarseilleLokomotiv Moscow 1-1 Marseille | UEFA Europa League Group E |
| 6 | Mon 20 Sep 2021 | 60-0 v UralUral 0-0 Lokomotiv Moscow | Russian Premier League |
| 7 | Sat 25 Sep 2021 | 6 0-0 v KhimkiKhimki 0-0 Lokomotiv Moscow | Russian Premier League |
| 8 | Thu 30 Sep 2021 | 60-2 v LazioLazio 2-0 Lokomotiv Moscow | UEFA Europa League Group E |
| 9 | Sun 3 Oct 2021 | 61-2 v RostovLokomotiv Moscow 1-2 Rostov | Russian Premier League |
| 10 | Sat 16 Oct 2021 | 62-2 v Rubin KazanRubin Kazan 2-2 Lokomotiv Moscow | Russian Premier League |
| 11 | Thu 21 Oct 2021 | 6 0-1 v GalatasarayLokomotiv Moscow 0-1 Galatasaray | UEFA Europa League Group E |
| 12 | Mon 25 Oct 2021 | 62-1 v SochiLokomotiv Moscow 2-1 Sochi | Russian Premier League |
| 13 | Sat 30 Oct 2021 | 62-1 v Nizhny NovgorodNizhny Novgorod 1-2 Lokomotiv Moscow | Russian Premier League |
| 14 | Thu 4 Nov 2021 | 6 1-1 v GalatasarayGalatasaray 1-1 Lokomotiv Moscow | UEFA Europa League Group E |
| 15 | Sun 7 Nov 2021 | 6 1-1 v Spartak MoscowSpartak Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 16 | Thu 25 Nov 2021 | 6 0-3 v LazioLokomotiv Moscow 0-3 Lazio | UEFA Europa League Group E |
| 17 | Mon 29 Nov 2021 | 61-3 v Arsenal TulaArsenal Tula 3-1 Lokomotiv Moscow | Russian Premier League |
| 18 | Sat 4 Dec 2021 | 6 0-1 v UralLokomotiv Moscow 0-1 Ural | Russian Premier League |
| 19 | Sun 12 Dec 2021 | 6 2-0 v UfaLokomotiv Moscow 2-0 Ufa | Russian Premier League |
| 20 | Sun 6 Mar 2022 | 63-2 v KhimkiLokomotiv Moscow 3-2 Khimki | Russian Premier League |
| 21 | Sat 12 Mar 2022 | 61-2 v CSKA MoscowLokomotiv Moscow 1-2 CSKA Moscow | Russian Premier League |
| 22 | Sat 19 Mar 2022 | 6 3-2 v Akhmat GroznyAkhmat Grozny 2-3 Lokomotiv Moscow | Russian Premier League |
| 23 | Sun 10 Apr 2022 | 61-4 v RostovRostov 4-1 Lokomotiv Moscow | Russian Premier League |
| 24 | Sat 23 Apr 2022 | 6 2-1 v Nizhny NovgorodLokomotiv Moscow 2-1 Nizhny Novgorod | Russian Premier League |
| 25 | Sat 30 Apr 2022 | 61-3 v Zenit St PetersburgZenit St Petersburg 3-1 Lokomotiv Moscow | Russian Premier League |
| 26 | Sat 14 May 2022 | 63-3 v Dinamo MoscowLokomotiv Moscow 3-3 Dinamo Moscow | Russian Premier League |
| 27 | Sat 21 May 2022 | 6 1-0 v Krylia SovetovKrylia Sovetov 0-1 Lokomotiv Moscow | Russian Premier League |
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