| 1 | Tue 6 Aug | 122-1 v FenerbahçeLille 2-1 Fenerbahçe | UEFA Champions League Third Qualifying Round |
| 2 | Tue 13 Aug | 121-1 v FenerbahçeFenerbahçe 1-1 Lille | UEFA Champions League Third Qualifying Round |
| 3 | Sat 17 Aug | 122-0 v ReimsReims 0-2 Lille | French Ligue 1 |
| 4 | Tue 20 Aug | 12 2-0 v Slavia PragueLille 2-0 Slavia Prague | UEFA Champions League Play-off |
| 5 | Sat 24 Aug | 122-0 v AngersLille 2-0 Angers | French Ligue 1 |
| 6 | Wed 28 Aug | 121-2 v Slavia PragueSlavia Prague 2-1 Lille | UEFA Champions League Play-off |
| 7 | Sun 1 Sep | 121-3 v Paris St GermainLille 1-3 Paris St Germain | French Ligue 1 |
| 8 | Fri 13 Sep | 120-1 v Saint ÉtienneSaint Étienne 1-0 Lille | French Ligue 1 |
| 9 | Tue 17 Sep | 120-2 v Sporting CPSporting CP 2-0 Lille | UEFA Champions League Matchday 1 |
| 10 | Sat 21 Sep | 123-3 v StrasbourgLille 3-3 Strasbourg | French Ligue 1 |
| 11 | Sat 28 Sep | 123-0 v Le HavreLe Havre 0-3 Lille | French Ligue 1 |
| 12 | Wed 2 Oct | 121-0 v Real MadridLille 1-0 Real Madrid | UEFA Champions League Matchday 2 |
| 13 | Sat 5 Oct | 122-1 v ToulouseLille 2-1 Toulouse | French Ligue 1 |
| 14 | Fri 18 Oct | 12 0-0 v MonacoMonaco 0-0 Lille | French Ligue 1 |
| 15 | Wed 23 Oct | 12 3-1 v Atlético MadridAtlético Madrid 1-3 Lille | UEFA Champions League Matchday 3 |
| 16 | Sat 26 Oct | 12 2-0 v LensLens 0-2 Lille | French Ligue 1 |
| 17 | Fri 1 Nov | 121-1 v LyonLille 1-1 Lyon | French Ligue 1 |
| 18 | Wed 27 Nov | 12 2-1 v BolognaBologna 1-2 Lille | UEFA Champions League Matchday 5 |
| 19 | Wed 11 Dec | 123-2 v Sturm GrazLille 3-2 Sturm Graz | UEFA Champions League Matchday 6 |
| 20 | Sat 14 Dec | 121-1 v MarseilleMarseille 1-1 Lille | French Ligue 1 |
| 21 | Sat 4 Jan | 121-1 v NantesLille 1-1 Nantes | French Ligue 1 |
| 22 | Fri 10 Jan | 120-0 v AuxerreAuxerre 0-0 Lille | French Ligue 1 |
| 23 | Fri 17 Jan | 122-1 v NiceLille 2-1 Nice | French Ligue 1 |
| 24 | Tue 21 Jan | 121-2 v LiverpoolLiverpool 2-1 Lille | UEFA Champions League Matchday 7 |
| 25 | Sat 25 Jan | 121-2 v StrasbourgStrasbourg 2-1 Lille | French Ligue 1 |
| 26 | Wed 29 Jan | 126-1 v FeyenoordLille 6-1 Feyenoord | UEFA Champions League Matchday 8 |
| 27 | Sat 1 Feb | 124-1 v Saint ÉtienneLille 4-1 Saint Étienne | French Ligue 1 |
| 28 | Sat 8 Feb | 121-2 v Le HavreLille 1-2 Le Havre | French Ligue 1 |
| 29 | Sun 16 Feb | 122-0 v RennesRennes 0-2 Lille | French Ligue 1 |
| 30 | Sat 22 Feb | 122-1 v MonacoLille 2-1 Monaco | French Ligue 1 |
| 31 | Sat 1 Mar | 12 1-4 v Paris St GermainParis St Germain 4-1 Lille | French Ligue 1 |
| 32 | Tue 4 Mar | 121-1 v Borussia DortmundBorussia Dortmund 1-1 Lille | UEFA Champions League Round of 16 |
| 33 | Sat 8 Mar | 121-0 v MontpellierLille 1-0 Montpellier | French Ligue 1 |
| 34 | Wed 12 Mar | 12 1-2 v Borussia DortmundLille 1-2 Borussia Dortmund | UEFA Champions League Round of 16 |
| 35 | Sun 30 Mar | 121-0 v LensLille 1-0 Lens | French Ligue 1 |
| 36 | Sat 5 Apr | 121-2 v LyonLyon 2-1 Lille | French Ligue 1 |
| 37 | Sat 12 Apr | 122-1 v ToulouseToulouse 1-2 Lille | French Ligue 1 |
| 38 | Sun 20 Apr | 123-1 v AuxerreLille 3-1 Auxerre | French Ligue 1 |
| 39 | Sun 27 Apr | 12 2-0 v AngersAngers 0-2 Lille | French Ligue 1 |
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