| 1 | Tue 6 Aug | 112-1 v FenerbahçeLille 2-1 Fenerbahçe | UEFA Champions League Third Qualifying Round |
| 2 | Tue 13 Aug | 111-1 v FenerbahçeFenerbahçe 1-1 Lille | UEFA Champions League Third Qualifying Round |
| 3 | Sat 17 Aug | 112-0 v ReimsReims 0-2 Lille | French Ligue 1 |
| 4 | Tue 20 Aug | 112-0 v Slavia PragueLille 2-0 Slavia Prague | UEFA Champions League Play-off |
| 5 | Sat 24 Aug | 112-0 v AngersLille 2-0 Angers | French Ligue 1 |
| 6 | Wed 28 Aug | 111-2 v Slavia PragueSlavia Prague 2-1 Lille | UEFA Champions League Play-off |
| 7 | Sun 1 Sep | 111-3 v Paris St GermainLille 1-3 Paris St Germain | French Ligue 1 |
| 8 | Tue 17 Sep | 110-2 v Sporting CPSporting CP 2-0 Lille | UEFA Champions League Matchday 1 |
| 9 | Sat 21 Sep | 113-3 v StrasbourgLille 3-3 Strasbourg | French Ligue 1 |
| 10 | Sat 28 Sep | 113-0 v Le HavreLe Havre 0-3 Lille | French Ligue 1 |
| 11 | Wed 2 Oct | 111-0 v Real MadridLille 1-0 Real Madrid | UEFA Champions League Matchday 2 |
| 12 | Sat 5 Oct | 112-1 v ToulouseLille 2-1 Toulouse | French Ligue 1 |
| 13 | Fri 18 Oct | 11 0-0 v MonacoMonaco 0-0 Lille | French Ligue 1 |
| 14 | Sat 26 Oct | 112-0 v LensLens 0-2 Lille | French Ligue 1 |
| 15 | Fri 1 Nov | 111-1 v LyonLille 1-1 Lyon | French Ligue 1 |
| 16 | Tue 5 Nov | 111-1 v JuventusLille 1-1 Juventus | UEFA Champions League Matchday 4 |
| 17 | Sun 24 Nov | 111-0 v RennesLille 1-0 Rennes | French Ligue 1 |
| 18 | Wed 27 Nov | 112-1 v BolognaBologna 1-2 Lille | UEFA Champions League Matchday 5 |
| 19 | Sun 1 Dec | 112-2 v MontpellierMontpellier 2-2 Lille | French Ligue 1 |
| 20 | Wed 11 Dec | 113-2 v Sturm GrazLille 3-2 Sturm Graz | UEFA Champions League Matchday 6 |
| 21 | Fri 10 Jan | 110-0 v AuxerreAuxerre 0-0 Lille | French Ligue 1 |
| 22 | Fri 17 Jan | 112-1 v NiceLille 2-1 Nice | French Ligue 1 |
| 23 | Tue 21 Jan | 111-2 v LiverpoolLiverpool 2-1 Lille | UEFA Champions League Matchday 7 |
| 24 | Sat 25 Jan | 111-2 v StrasbourgStrasbourg 2-1 Lille | French Ligue 1 |
| 25 | Wed 29 Jan | 116-1 v FeyenoordLille 6-1 Feyenoord | UEFA Champions League Matchday 8 |
| 26 | Sat 1 Feb | 114-1 v Saint ÉtienneLille 4-1 Saint Étienne | French Ligue 1 |
| 27 | Sat 8 Feb | 111-2 v Le HavreLille 1-2 Le Havre | French Ligue 1 |
| 28 | Sun 16 Feb | 112-0 v RennesRennes 0-2 Lille | French Ligue 1 |
| 29 | Wed 12 Mar | 111-2 v Borussia DortmundLille 1-2 Borussia Dortmund | UEFA Champions League Round of 16 |
| 30 | Sat 15 Mar | 110-1 v NantesNantes 1-0 Lille | French Ligue 1 |
| 31 | Sat 5 Apr | 111-2 v LyonLyon 2-1 Lille | French Ligue 1 |
| 32 | Sat 12 Apr | 112-1 v ToulouseToulouse 1-2 Lille | French Ligue 1 |
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