| 1 | Tue 13 Aug | 171-1 v FenerbahçeFenerbahçe 1-1 Lille | UEFA Champions League Third Qualifying Round |
| 2 | Sat 17 Aug | 17 2-0 v ReimsReims 0-2 Lille | French Ligue 1 |
| 3 | Tue 20 Aug | 172-0 v Slavia PragueLille 2-0 Slavia Prague | UEFA Champions League Play-off |
| 4 | Sat 24 Aug | 172-0 v AngersLille 2-0 Angers | French Ligue 1 |
| 5 | Wed 28 Aug | 171-2 v Slavia PragueSlavia Prague 2-1 Lille | UEFA Champions League Play-off |
| 6 | Sun 1 Sep | 17 1-3 v Paris St GermainLille 1-3 Paris St Germain | French Ligue 1 |
| 7 | Fri 18 Oct | 170-0 v MonacoMonaco 0-0 Lille | French Ligue 1 |
| 8 | Wed 23 Oct | 173-1 v Atlético MadridAtlético Madrid 1-3 Lille | UEFA Champions League Matchday 3 |
| 9 | Sat 26 Oct | 172-0 v LensLens 0-2 Lille | French Ligue 1 |
| 10 | Fri 1 Nov | 17 1-1 v LyonLille 1-1 Lyon | French Ligue 1 |
| 11 | Tue 5 Nov | 171-1 v JuventusLille 1-1 Juventus | UEFA Champions League Matchday 4 |
| 12 | Sun 10 Nov | 172-2 v NiceNice 2-2 Lille | French Ligue 1 |
| 13 | Wed 27 Nov | 172-1 v BolognaBologna 1-2 Lille | UEFA Champions League Matchday 5 |
| 14 | Sun 1 Dec | 17 2-2 v MontpellierMontpellier 2-2 Lille | French Ligue 1 |
| 15 | Fri 6 Dec | 173-1 v BrestLille 3-1 Brest | French Ligue 1 |
| 16 | Wed 11 Dec | 173-2 v Sturm GrazLille 3-2 Sturm Graz | UEFA Champions League Matchday 6 |
| 17 | Sat 14 Dec | 171-1 v MarseilleMarseille 1-1 Lille | French Ligue 1 |
| 18 | Sat 4 Jan | 171-1 v NantesLille 1-1 Nantes | French Ligue 1 |
| 19 | Fri 17 Jan | 172-1 v NiceLille 2-1 Nice | French Ligue 1 |
| 20 | Tue 21 Jan | 171-2 v LiverpoolLiverpool 2-1 Lille | UEFA Champions League Matchday 7 |
| 21 | Wed 29 Jan | 17 6-1 v FeyenoordLille 6-1 Feyenoord | UEFA Champions League Matchday 8 |
| 22 | Sat 1 Feb | 174-1 v Saint ÉtienneLille 4-1 Saint Étienne | French Ligue 1 |
| 23 | Sun 16 Feb | 172-0 v RennesRennes 0-2 Lille | French Ligue 1 |
| 24 | Sat 22 Feb | 172-1 v MonacoLille 2-1 Monaco | French Ligue 1 |
| 25 | Sat 1 Mar | 171-4 v Paris St GermainParis St Germain 4-1 Lille | French Ligue 1 |
| 26 | Tue 4 Mar | 171-1 v Borussia DortmundBorussia Dortmund 1-1 Lille | UEFA Champions League Round of 16 |
| 27 | Wed 12 Mar | 17 1-2 v Borussia DortmundLille 1-2 Borussia Dortmund | UEFA Champions League Round of 16 |
| 28 | Sun 30 Mar | 171-0 v LensLille 1-0 Lens | French Ligue 1 |
| 29 | Sat 5 Apr | 171-2 v LyonLyon 2-1 Lille | French Ligue 1 |
| 30 | Sun 20 Apr | 173-1 v AuxerreLille 3-1 Auxerre | French Ligue 1 |
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