| 1 | Tue 17 Sep | 200-2 v Sporting CPSporting CP 2-0 Lille | UEFA Champions League Matchday 1 |
| 2 | Sat 21 Sep | 203-3 v StrasbourgLille 3-3 Strasbourg | French Ligue 1 |
| 3 | Sat 28 Sep | 203-0 v Le HavreLe Havre 0-3 Lille | French Ligue 1 |
| 4 | Wed 2 Oct | 201-0 v Real MadridLille 1-0 Real Madrid | UEFA Champions League Matchday 2 |
| 5 | Sat 5 Oct | 202-1 v ToulouseLille 2-1 Toulouse | French Ligue 1 |
| 6 | Fri 18 Oct | 200-0 v MonacoMonaco 0-0 Lille | French Ligue 1 |
| 7 | Fri 1 Nov | 201-1 v LyonLille 1-1 Lyon | French Ligue 1 |
| 8 | Tue 5 Nov | 201-1 v JuventusLille 1-1 Juventus | UEFA Champions League Matchday 4 |
| 9 | Sun 10 Nov | 202-2 v NiceNice 2-2 Lille | French Ligue 1 |
| 10 | Sun 24 Nov | 201-0 v RennesLille 1-0 Rennes | French Ligue 1 |
| 11 | Sun 1 Dec | 20 2-2 v MontpellierMontpellier 2-2 Lille | French Ligue 1 |
| 12 | Wed 11 Dec | 20 3-2 v Sturm GrazLille 3-2 Sturm Graz | UEFA Champions League Matchday 6 |
| 13 | Sat 14 Dec | 201-1 v MarseilleMarseille 1-1 Lille | French Ligue 1 |
| 14 | Fri 17 Jan | 202-1 v NiceLille 2-1 Nice | French Ligue 1 |
| 15 | Tue 21 Jan | 201-2 v LiverpoolLiverpool 2-1 Lille | UEFA Champions League Matchday 7 |
| 16 | Sat 25 Jan | 20 1-2 v StrasbourgStrasbourg 2-1 Lille | French Ligue 1 |
| 17 | Wed 29 Jan | 206-1 v FeyenoordLille 6-1 Feyenoord | UEFA Champions League Matchday 8 |
| 18 | Sat 1 Feb | 204-1 v Saint ÉtienneLille 4-1 Saint Étienne | French Ligue 1 |
| 19 | Sat 8 Feb | 20 1-2 v Le HavreLille 1-2 Le Havre | French Ligue 1 |
| 20 | Sun 16 Feb | 202-0 v RennesRennes 0-2 Lille | French Ligue 1 |
| 21 | Sat 1 Mar | 201-4 v Paris St GermainParis St Germain 4-1 Lille | French Ligue 1 |
| 22 | Tue 4 Mar | 201-1 v Borussia DortmundBorussia Dortmund 1-1 Lille | UEFA Champions League Round of 16 |
| 23 | Sat 8 Mar | 201-0 v MontpellierLille 1-0 Montpellier | French Ligue 1 |
| 24 | Sat 15 Mar | 20 0-1 v NantesNantes 1-0 Lille | French Ligue 1 |
| 25 | Sun 30 Mar | 201-0 v LensLille 1-0 Lens | French Ligue 1 |
| 26 | Sat 5 Apr | 201-2 v LyonLyon 2-1 Lille | French Ligue 1 |
| 27 | Sat 12 Apr | 202-1 v ToulouseToulouse 1-2 Lille | French Ligue 1 |
| 28 | Sun 27 Apr | 202-0 v AngersAngers 0-2 Lille | French Ligue 1 |
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