| 1 | Sat 14 Jan 2023 | 43 0-0 v BarrowLeyton Orient 0-0 Barrow | Sky Bet League Two |
| 2 | Sat 21 Jan 2023 | 430-3 v StevenageStevenage 3-0 Leyton Orient | Sky Bet League Two |
| 3 | Sat 4 Feb 2023 | 431-0 v AFC WimbledonLeyton Orient 1-0 AFC Wimbledon | Sky Bet League Two |
| 4 | Tue 7 Feb 2023 | 432-0 v Crewe AlexandraCrewe Alexandra 0-2 Leyton Orient | Sky Bet League Two |
| 5 | Sat 11 Feb 2023 | 431-1 v WalsallWalsall 1-1 Leyton Orient | Sky Bet League Two |
| 6 | Tue 14 Feb 2023 | 432-1 v RochdaleLeyton Orient 2-1 Rochdale | Sky Bet League Two |
| 7 | Sat 18 Feb 2023 | 431-0 v Crawley TownLeyton Orient 1-0 Crawley Town | Sky Bet League Two |
| 8 | Sat 25 Feb 2023 | 432-2 v Grimsby TownGrimsby Town 2-2 Leyton Orient | Sky Bet League Two |
| 9 | Sat 4 Mar 2023 | 43 1-1 v Swindon TownLeyton Orient 1-1 Swindon Town | Sky Bet League Two |
| 10 | Sat 18 Mar 2023 | 43 2-2 v Colchester UnitedLeyton Orient 2-2 Colchester United | Sky Bet League Two |
| 11 | Sat 25 Mar 2023 | 431-1 v Hartlepool UnitedHartlepool United 1-1 Leyton Orient | Sky Bet League Two |
| 12 | Sat 1 Apr 2023 | 431-0 v Carlisle UnitedLeyton Orient 1-0 Carlisle United | Sky Bet League Two |
| 13 | Fri 7 Apr 2023 | 432-0 v Salford CitySalford City 0-2 Leyton Orient | Sky Bet League Two |
| 14 | Sat 15 Apr 2023 | 432-0 v Sutton UnitedSutton United 0-2 Leyton Orient | Sky Bet League Two |
| 15 | Tue 18 Apr 2023 | 43 0-2 v GillinghamGillingham 2-0 Leyton Orient | Sky Bet League Two |
| 16 | Sat 22 Apr 2023 | 432-0 v Crewe AlexandraLeyton Orient 2-0 Crewe Alexandra | Sky Bet League Two |
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