| 1 | Sat 7 Aug 2021 | 71-1 v Salford CitySalford City 1-1 Leyton Orient | Sky Bet League Two |
| 2 | Sat 2 Oct 2021 | 72-3 v Port ValePort Vale 3-2 Leyton Orient | Sky Bet League Two |
| 3 | Sat 16 Oct 2021 | 7 0-0 v WalsallLeyton Orient 0-0 Walsall | Sky Bet League Two |
| 4 | Tue 19 Oct 2021 | 71-1 v Forest Green RoversLeyton Orient 1-1 Forest Green Rovers | Sky Bet League Two |
| 5 | Tue 9 Nov 2021 | 7 1-0 v Charlton AthleticLeyton Orient 1-0 Charlton Athletic | Papa John’s Trophy |
| 6 | Sat 20 Nov 2021 | 74-1 v Sutton UnitedLeyton Orient 4-1 Sutton United | Sky Bet League Two |
| 7 | Tue 23 Nov 2021 | 71-1 v Scunthorpe UnitedScunthorpe United 1-1 Leyton Orient | Sky Bet League Two |
| 8 | Sat 18 Dec 2021 | 70-1 v Tranmere RoversTranmere Rovers 1-0 Leyton Orient | Sky Bet League Two |
| 9 | Sun 9 Jan 2022 | 70-2 v Stoke CityStoke City 2-0 Leyton Orient | Emirates FA Cup Third Round |
| 10 | Sat 22 Jan 2022 | 70-0 v Port ValeLeyton Orient 0-0 Port Vale | Sky Bet League Two |
| 11 | Tue 25 Jan 2022 | 70-1 v Newport CountyLeyton Orient 0-1 Newport County | Sky Bet League Two |
| 12 | Sat 29 Jan 2022 | 70-2 v Mansfield TownMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 13 | Tue 1 Mar 2022 | 7 2-2 v Colchester UnitedColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 14 | Sat 5 Mar 2022 | 72-2 v StevenageLeyton Orient 2-2 Stevenage | Sky Bet League Two |
| 15 | Sat 12 Mar 2022 | 70-0 v Hartlepool UnitedHartlepool United 0-0 Leyton Orient | Sky Bet League Two |
| 16 | Tue 15 Mar 2022 | 71-1 v Forest Green RoversForest Green Rovers 1-1 Leyton Orient | Sky Bet League Two |
| 17 | Sat 19 Mar 2022 | 73-1 v RochdaleLeyton Orient 3-1 Rochdale | Sky Bet League Two |
| 18 | Tue 22 Mar 2022 | 73-0 v Harrogate TownHarrogate Town 0-3 Leyton Orient | Sky Bet League Two |
| 19 | Sat 26 Mar 2022 | 72-0 v BarrowLeyton Orient 2-0 Barrow | Sky Bet League Two |
| 20 | Tue 29 Mar 2022 | 70-2 v Oldham AthleticOldham Athletic 2-0 Leyton Orient | Sky Bet League Two |
| 21 | Sat 9 Apr 2022 | 70-1 v Sutton UnitedSutton United 1-0 Leyton Orient | Sky Bet League Two |
| 22 | Fri 15 Apr 2022 | 73-0 v Scunthorpe UnitedLeyton Orient 3-0 Scunthorpe United | Sky Bet League Two |
| 23 | Mon 18 Apr 2022 | 72-1 v Swindon TownSwindon Town 1-2 Leyton Orient | Sky Bet League Two |
| 24 | Sat 23 Apr 2022 | 72-4 v Northampton TownLeyton Orient 2-4 Northampton Town | Sky Bet League Two |
| 25 | Sat 30 Apr 2022 | 72-0 v Crawley TownCrawley Town 0-2 Leyton Orient | Sky Bet League Two |
| 26 | Sat 7 May 2022 | 70-1 v Tranmere RoversLeyton Orient 0-1 Tranmere Rovers | Sky Bet League Two |
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