| 1 | Sat 7 Aug 2021 | 81-1 v Salford CitySalford City 1-1 Leyton Orient | Sky Bet League Two |
| 2 | Sat 21 Aug 2021 | 8 1-1 v Carlisle UnitedCarlisle United 1-1 Leyton Orient | Sky Bet League Two |
| 3 | Sat 28 Aug 2021 | 82-0 v Bradford CityLeyton Orient 2-0 Bradford City | Sky Bet League Two |
| 4 | Sat 4 Sep 2021 | 82-2 v Newport CountyNewport County 2-2 Leyton Orient | Sky Bet League Two |
| 5 | Sat 11 Sep 2021 | 84-0 v Oldham AthleticLeyton Orient 4-0 Oldham Athletic | Sky Bet League Two |
| 6 | Sat 18 Sep 2021 | 8 3-1 v Bristol RoversBristol Rovers 1-3 Leyton Orient | Sky Bet League Two |
| 7 | Sat 25 Sep 2021 | 80-0 v Mansfield TownLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 8 | Sat 2 Oct 2021 | 82-3 v Port ValePort Vale 3-2 Leyton Orient | Sky Bet League Two |
| 9 | Tue 5 Oct 2021 | 84-0 v Crawley TownCrawley Town 0-4 Leyton Orient | Papa John’s Trophy |
| 10 | Sat 9 Oct 2021 | 81-1 v BarrowBarrow 1-1 Leyton Orient | Sky Bet League Two |
| 11 | Sat 16 Oct 2021 | 80-0 v WalsallLeyton Orient 0-0 Walsall | Sky Bet League Two |
| 12 | Tue 19 Oct 2021 | 81-1 v Forest Green RoversLeyton Orient 1-1 Forest Green Rovers | Sky Bet League Two |
| 13 | Sat 23 Oct 2021 | 80-0 v StevenageStevenage 0-0 Leyton Orient | Sky Bet League Two |
| 14 | Sat 30 Oct 2021 | 8 5-0 v Hartlepool UnitedLeyton Orient 5-0 Hartlepool United | Sky Bet League Two |
| 15 | Sat 6 Nov 2021 | 8 1-0 v Ebbsfleet UnitedLeyton Orient 1-0 Ebbsfleet United | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 82-2 v RochdaleRochdale 2-2 Leyton Orient | Sky Bet League Two |
| 17 | Sat 20 Nov 2021 | 84-1 v Sutton UnitedLeyton Orient 4-1 Sutton United | Sky Bet League Two |
| 18 | Tue 23 Nov 2021 | 81-1 v Scunthorpe UnitedScunthorpe United 1-1 Leyton Orient | Sky Bet League Two |
| 19 | Sat 4 Dec 2021 | 84-0 v Tranmere RoversLeyton Orient 4-0 Tranmere Rovers | Emirates FA Cup Second Round |
| 20 | Tue 7 Dec 2021 | 8 4-1 v Swindon TownLeyton Orient 4-1 Swindon Town | Sky Bet League Two |
| 21 | Sat 11 Dec 2021 | 8 1-2 v Crawley TownLeyton Orient 1-2 Crawley Town | Sky Bet League Two |
| 22 | Sat 18 Dec 2021 | 80-1 v Tranmere RoversTranmere Rovers 1-0 Leyton Orient | Sky Bet League Two |
| 23 | Sun 9 Jan 2022 | 80-2 v Stoke CityStoke City 2-0 Leyton Orient | Emirates FA Cup Third Round |
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