| 1 | Tue 2 Feb 2021 | 350-0 v Crawley TownCrawley Town 0-0 Leyton Orient | Sky Bet League Two |
| 2 | Sat 6 Feb 2021 | 350-0 v Colchester UnitedLeyton Orient 0-0 Colchester United | Sky Bet League Two |
| 3 | Sat 20 Feb 2021 | 351-1 v Port ValeLeyton Orient 1-1 Port Vale | Sky Bet League Two |
| 4 | Tue 23 Feb 2021 | 350-1 v Bradford CityBradford City 1-0 Leyton Orient | Sky Bet League Two |
| 5 | Sat 27 Feb 2021 | 351-3 v Tranmere RoversLeyton Orient 1-3 Tranmere Rovers | Sky Bet League Two |
| 6 | Tue 2 Mar 2021 | 351-0 v Grimsby TownGrimsby Town 0-1 Leyton Orient | Sky Bet League Two |
| 7 | Sat 6 Mar 2021 | 350-4 v Exeter CityExeter City 4-0 Leyton Orient | Sky Bet League Two |
| 8 | Tue 9 Mar 2021 | 350-0 v StevenageLeyton Orient 0-0 Stevenage | Sky Bet League Two |
| 9 | Sat 13 Mar 2021 | 351-1 v Scunthorpe UnitedLeyton Orient 1-1 Scunthorpe United | Sky Bet League Two |
| 10 | Sat 27 Mar 2021 | 35 2-1 v Oldham AthleticLeyton Orient 2-1 Oldham Athletic | Sky Bet League Two |
| 11 | Sat 10 Apr 2021 | 350-1 v Cheltenham TownCheltenham Town 1-0 Leyton Orient | Sky Bet League Two |
| 12 | Tue 13 Apr 2021 | 352-2 v Harrogate TownHarrogate Town 2-2 Leyton Orient | Sky Bet League Two |
| 13 | Sat 17 Apr 2021 | 352-0 v BarrowLeyton Orient 2-0 Barrow | Sky Bet League Two |
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