| 1 | Sat 23 Jan 2021 | 280-1 v Forest Green RoversLeyton Orient 0-1 Forest Green Rovers | Sky Bet League Two |
| 2 | Sat 30 Jan 2021 | 280-2 v Bolton WanderersBolton Wanderers 2-0 Leyton Orient | Sky Bet League Two |
| 3 | Tue 2 Feb 2021 | 280-0 v Crawley TownCrawley Town 0-0 Leyton Orient | Sky Bet League Two |
| 4 | Sat 6 Feb 2021 | 280-0 v Colchester UnitedLeyton Orient 0-0 Colchester United | Sky Bet League Two |
| 5 | Sat 20 Feb 2021 | 281-1 v Port ValeLeyton Orient 1-1 Port Vale | Sky Bet League Two |
| 6 | Tue 23 Feb 2021 | 280-1 v Bradford CityBradford City 1-0 Leyton Orient | Sky Bet League Two |
| 7 | Sat 27 Feb 2021 | 281-3 v Tranmere RoversLeyton Orient 1-3 Tranmere Rovers | Sky Bet League Two |
| 8 | Tue 2 Mar 2021 | 281-0 v Grimsby TownGrimsby Town 0-1 Leyton Orient | Sky Bet League Two |
| 9 | Sat 6 Mar 2021 | 280-4 v Exeter CityExeter City 4-0 Leyton Orient | Sky Bet League Two |
| 10 | Tue 9 Mar 2021 | 280-0 v StevenageLeyton Orient 0-0 Stevenage | Sky Bet League Two |
| 11 | Sat 13 Mar 2021 | 281-1 v Scunthorpe UnitedLeyton Orient 1-1 Scunthorpe United | Sky Bet League Two |
| 12 | Sat 10 Apr 2021 | 280-1 v Cheltenham TownCheltenham Town 1-0 Leyton Orient | Sky Bet League Two |
| 13 | Tue 13 Apr 2021 | 282-2 v Harrogate TownHarrogate Town 2-2 Leyton Orient | Sky Bet League Two |
| 14 | Sat 17 Apr 2021 | 282-0 v BarrowLeyton Orient 2-0 Barrow | Sky Bet League Two |
| 15 | Sat 24 Apr 2021 | 281-2 v Southend UnitedSouthend United 2-1 Leyton Orient | Sky Bet League Two |
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