| 1 | Sat 23 Sep 2017 | 2-2 v Aldershot TownAldershot Town 2-2 Leyton Orient | National League |
| 2 | Sat 30 Sep 2017 | 1-2 v AFC FyldeLeyton Orient 1-2 AFC Fylde | National League |
| 3 | Wed 4 Oct 2017 | 1-2 v Tranmere RoversTranmere Rovers 2-1 Leyton Orient | National League |
| 4 | Sat 7 Oct 2017 | 2-2 v BarrowBarrow 2-2 Leyton Orient | National League |
| 5 | Sat 21 Oct 2017 | 0-1 v Macclesfield TownLeyton Orient 0-1 Macclesfield Town | National League |
| 6 | Tue 24 Oct 2017 | 0-2 v GatesheadLeyton Orient 0-2 Gateshead | National League |
| 7 | Sat 28 Oct 2017 | 2-2 v WrexhamWrexham 2-2 Leyton Orient | National League |
| 8 | Sat 11 Nov 2017 | 1-2 v Ebbsfleet UnitedEbbsfleet United 2-1 Leyton Orient | National League |
| 9 | Sat 18 Nov 2017 | 1-1 v Dover AthleticLeyton Orient 1-1 Dover Athletic | National League |
| 10 | Tue 21 Nov 2017 | 2-2 v ChesterLeyton Orient 2-2 Chester | National League |
| 11 | Sat 10 Feb 2018 | 1-1 v Tranmere RoversLeyton Orient 1-1 Tranmere Rovers | National League |
| 12 | Sat 17 Feb 2018 | 1-0 v AFC FyldeAFC Fylde 0-1 Leyton Orient | National League |
| 13 | Tue 20 Feb 2018 | 1-0 v ChesterChester 0-1 Leyton Orient | National League |
| 14 | Sat 24 Feb 2018 | 3-3 v GatesheadLeyton Orient 3-3 Gateshead | Buildbase FA Trophy Quarter Final |
| 15 | Sat 10 Mar 2018 | 1-1 v Ebbsfleet UnitedLeyton Orient 1-1 Ebbsfleet United | National League |
| 16 | Tue 13 Mar 2018 | 0-1 v Torquay UnitedLeyton Orient 0-1 Torquay United | National League |
| 17 | Sat 17 Mar 2018 | 0-0 v EastleighEastleigh 0-0 Leyton Orient | National League |
| 18 | Sat 24 Mar 2018 | 3-0 v WokingLeyton Orient 3-0 Woking | National League |
| 19 | Fri 30 Mar 2018 | 3-1 v GuiseleyGuiseley 1-3 Leyton Orient | National League |
| 20 | Sat 7 Apr 2018 | 4-1 v BarrowLeyton Orient 4-1 Barrow | National League |
| 21 | Sat 14 Apr 2018 | 1-1 v Macclesfield TownMacclesfield Town 1-1 Leyton Orient | National League |
| 22 | Tue 17 Apr 2018 | 0-1 v Hartlepool UnitedHartlepool United 1-0 Leyton Orient | National League |
| 23 | Sat 21 Apr 2018 | 1-0 v WrexhamLeyton Orient 1-0 Wrexham | National League |
| 24 | Tue 24 Apr 2018 | 0-1 v Maidenhead UnitedLeyton Orient 0-1 Maidenhead United | National League |
| 25 | Sat 28 Apr 2018 | 3-1 v GatesheadGateshead 1-3 Leyton Orient | National League |
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