| 1 | Sat 5 Aug 2017 | 0-2 v Sutton UnitedSutton United 2-0 Leyton Orient | National League |
| 2 | Tue 8 Aug 2017 | 53-1 v Solihull MoorsLeyton Orient 3-1 Solihull Moors | National League |
| 3 | Sat 12 Aug 2017 | 52-0 v Maidstone UnitedLeyton Orient 2-0 Maidstone United | National League |
| 4 | Tue 15 Aug 2017 | 51-6 v BromleyBromley 6-1 Leyton Orient | National League |
| 5 | Sat 19 Aug 2017 | 52-0 v WokingWoking 0-2 Leyton Orient | National League |
| 6 | Sat 26 Aug 2017 | 51-1 v EastleighLeyton Orient 1-1 Eastleigh | National League |
| 7 | Mon 28 Aug 2017 | 51-0 v Maidenhead UnitedMaidenhead United 0-1 Leyton Orient | National League |
| 8 | Sat 2 Sep 2017 | 54-1 v GuiseleyLeyton Orient 4-1 Guiseley | National League |
| 9 | Sat 9 Sep 2017 | 50-2 v Boreham WoodBoreham Wood 2-0 Leyton Orient | National League |
| 10 | Sat 27 Jan 2018 | 52-3 v Aldershot TownLeyton Orient 2-3 Aldershot Town | National League |
| 11 | Tue 30 Jan 2018 | 52-1 v FC Halifax TownFC Halifax Town 1-2 Leyton Orient | National League |
| 12 | Sat 3 Feb 2018 | 54-3 v Dover AthleticDover Athletic 3-4 Leyton Orient | Buildbase FA Trophy Third Round |
| 13 | Sat 10 Feb 2018 | 51-1 v Tranmere RoversLeyton Orient 1-1 Tranmere Rovers | National League |
| 14 | Sat 17 Feb 2018 | 51-0 v AFC FyldeAFC Fylde 0-1 Leyton Orient | National League |
| 15 | Tue 20 Feb 2018 | 51-0 v ChesterChester 0-1 Leyton Orient | National League |
| 16 | Sat 10 Mar 2018 | 51-1 v Ebbsfleet UnitedLeyton Orient 1-1 Ebbsfleet United | National League |
| 17 | Tue 13 Mar 2018 | 50-1 v Torquay UnitedLeyton Orient 0-1 Torquay United | National League |
| 18 | Sat 17 Mar 2018 | 50-0 v EastleighEastleigh 0-0 Leyton Orient | National League |
| 19 | Sat 24 Mar 2018 | 53-0 v WokingLeyton Orient 3-0 Woking | National League |
| 20 | Fri 30 Mar 2018 | 53-1 v GuiseleyGuiseley 1-3 Leyton Orient | National League |
| 21 | Sat 7 Apr 2018 | 54-1 v BarrowLeyton Orient 4-1 Barrow | National League |
| 22 | Sat 14 Apr 2018 | 51-1 v Macclesfield TownMacclesfield Town 1-1 Leyton Orient | National League |
| 23 | Tue 17 Apr 2018 | 50-1 v Hartlepool UnitedHartlepool United 1-0 Leyton Orient | National League |
| 24 | Sat 28 Apr 2018 | 53-1 v GatesheadGateshead 1-3 Leyton Orient | National League |
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