| 1 | Tue 14 Aug 2012 | 61-1 v Charlton AthleticCharlton Athletic 1-1 Leyton Orient | Capital One Cup First Round |
| 2 | Sat 18 Aug 2012 | 61-3 v Tranmere RoversTranmere Rovers 3-1 Leyton Orient | npower League One |
| 3 | Tue 21 Aug 2012 | 60-1 v StevenageLeyton Orient 0-1 Stevenage | npower League One |
| 4 | Wed 29 Aug 2012 | 60-5 v EvertonEverton 5-0 Leyton Orient | Capital One Cup Second Round |
| 5 | Sat 29 Sep 2012 | 60-2 v Doncaster RoversLeyton Orient 0-2 Doncaster Rovers | npower League One |
| 6 | Tue 2 Oct 2012 | 62-1 v WalsallWalsall 1-2 Leyton Orient | npower League One |
| 7 | Tue 9 Oct 2012 | 61-0 v BarnetLeyton Orient 1-0 Barnet | Johnstone's Paint Trophy Second Round |
| 8 | Wed 14 Nov 2012 | 62-0 v Gloucester CityGloucester City 0-2 Leyton Orient | FA Cup with Budweiser First Round |
| 9 | Tue 20 Nov 2012 | 63-2 v PortsmouthPortsmouth 2-3 Leyton Orient | npower League One |
| 10 | Sat 24 Nov 2012 | 62-0 v Preston North EndLeyton Orient 2-0 Preston North End | npower League One |
| 11 | Sun 2 Dec 2012 | 64-2 v Alfreton TownAlfreton Town 2-4 Leyton Orient | FA Cup with Budweiser Second Round |
| 12 | Wed 5 Dec 2012 | 63-0 v Northampton TownNorthampton Town 0-3 Leyton Orient | Johnstone's Paint Trophy Southern Area Quarter Final |
| 13 | Sat 8 Dec 2012 | 62-0 v BuryBury 0-2 Leyton Orient | npower League One |
| 14 | Sat 15 Dec 2012 | 61-3 v Scunthorpe UnitedLeyton Orient 1-3 Scunthorpe United | npower League One |
| 15 | Sat 29 Dec 2012 | 62-1 v WalsallLeyton Orient 2-1 Walsall | npower League One |
| 16 | Tue 1 Jan 2013 | 60-3 v Yeovil TownYeovil Town 3-0 Leyton Orient | npower League One |
| 17 | Sat 5 Jan 2013 | 61-1 v Hull CityHull City 1-1 Leyton Orient | FA Cup with Budweiser Third Round |
| 18 | Tue 8 Jan 2013 | 61-0 v Yeovil TownLeyton Orient 1-0 Yeovil Town | Johnstone's Paint Trophy Southern Area Semi Final |
| 19 | Sat 12 Jan 2013 | 61-1 v Crewe AlexandraLeyton Orient 1-1 Crewe Alexandra | npower League One |
| 20 | Tue 15 Jan 2013 | 61-2 v Hull CityLeyton Orient 1-2 Hull City | FA Cup with Budweiser Third Round Replay |
| 21 | Tue 22 Jan 2013 | 62-2 v BrentfordBrentford 2-2 Leyton Orient | npower League One |
| 22 | Sat 26 Jan 2013 | 62-1 v Notts CountyLeyton Orient 2-1 Notts County | npower League One |
| 23 | Tue 29 Jan 2013 | 60-0 v Swindon TownLeyton Orient 0-0 Swindon Town | npower League One |
| 24 | Sat 2 Feb 2013 | 61-0 v StevenageStevenage 0-1 Leyton Orient | npower League One |
| 25 | Tue 5 Feb 2013 | 60-1 v Southend UnitedLeyton Orient 0-1 Southend United | Johnstone's Paint Trophy Southern Area Final |
| 26 | Sat 9 Feb 2013 | 62-1 v Tranmere RoversLeyton Orient 2-1 Tranmere Rovers | npower League One |
| 27 | Sat 16 Feb 2013 | 61-2 v Hartlepool UnitedHartlepool United 2-1 Leyton Orient | npower League One |
| 28 | Wed 20 Feb 2013 | 62-2 v Southend UnitedSouthend United 2-2 Leyton Orient | Johnstone's Paint Trophy Southern Area Final |
| 29 | Sat 23 Feb 2013 | 60-1 v Crawley TownLeyton Orient 0-1 Crawley Town | npower League One |
| 30 | Tue 26 Feb 2013 | 60-0 v Sheffield UnitedSheffield United 0-0 Leyton Orient | npower League One |
| 31 | Sat 2 Mar 2013 | 63-1 v BournemouthLeyton Orient 3-1 Bournemouth | npower League One |
| 32 | Wed 6 Mar 2013 | 61-1 v Notts CountyNotts County 1-1 Leyton Orient | npower League One |
| 33 | Sat 9 Mar 2013 | 62-0 v Shrewsbury TownShrewsbury Town 0-2 Leyton Orient | npower League One |
| 34 | Tue 12 Mar 2013 | 61-0 v PortsmouthLeyton Orient 1-0 Portsmouth | npower League One |
| 35 | Mon 1 Apr 2013 | 62-0 v BuryLeyton Orient 2-0 Bury | npower League One |
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