| 1 | Sat 18 Aug 2012 | 11-3 v Tranmere RoversTranmere Rovers 3-1 Leyton Orient | npower League One |
| 2 | Tue 21 Aug 2012 | 10-1 v StevenageLeyton Orient 0-1 Stevenage | npower League One |
| 3 | Wed 29 Aug 2012 | 10-5 v EvertonEverton 5-0 Leyton Orient | Capital One Cup Second Round |
| 4 | Wed 5 Dec 2012 | 13-0 v Northampton TownNorthampton Town 0-3 Leyton Orient | Johnstone's Paint Trophy Southern Area Quarter Final |
| 5 | Sat 29 Dec 2012 | 12-1 v WalsallLeyton Orient 2-1 Walsall | npower League One |
| 6 | Tue 1 Jan 2013 | 10-3 v Yeovil TownYeovil Town 3-0 Leyton Orient | npower League One |
| 7 | Sat 5 Jan 2013 | 11-1 v Hull CityHull City 1-1 Leyton Orient | FA Cup with Budweiser Third Round |
| 8 | Tue 8 Jan 2013 | 11-0 v Yeovil TownLeyton Orient 1-0 Yeovil Town | Johnstone's Paint Trophy Southern Area Semi Final |
| 9 | Sat 12 Jan 2013 | 11-1 v Crewe AlexandraLeyton Orient 1-1 Crewe Alexandra | npower League One |
| 10 | Tue 15 Jan 2013 | 11-2 v Hull CityLeyton Orient 1-2 Hull City | FA Cup with Budweiser Third Round Replay |
| 11 | Sat 19 Jan 2013 | 10-2 v Doncaster RoversDoncaster Rovers 2-0 Leyton Orient | npower League One |
| 12 | Tue 22 Jan 2013 | 12-2 v BrentfordBrentford 2-2 Leyton Orient | npower League One |
| 13 | Sat 26 Jan 2013 | 12-1 v Notts CountyLeyton Orient 2-1 Notts County | npower League One |
| 14 | Tue 29 Jan 2013 | 10-0 v Swindon TownLeyton Orient 0-0 Swindon Town | npower League One |
| 15 | Sat 2 Feb 2013 | 11-0 v StevenageStevenage 0-1 Leyton Orient | npower League One |
| 16 | Tue 5 Feb 2013 | 10-1 v Southend UnitedLeyton Orient 0-1 Southend United | Johnstone's Paint Trophy Southern Area Final |
| 17 | Sat 9 Feb 2013 | 12-1 v Tranmere RoversLeyton Orient 2-1 Tranmere Rovers | npower League One |
| 18 | Sat 16 Feb 2013 | 11-2 v Hartlepool UnitedHartlepool United 2-1 Leyton Orient | npower League One |
| 19 | Wed 20 Feb 2013 | 12-2 v Southend UnitedSouthend United 2-2 Leyton Orient | Johnstone's Paint Trophy Southern Area Final |
| 20 | Sat 23 Feb 2013 | 10-1 v Crawley TownLeyton Orient 0-1 Crawley Town | npower League One |
| 21 | Tue 26 Feb 2013 | 10-0 v Sheffield UnitedSheffield United 0-0 Leyton Orient | npower League One |
| 22 | Sat 2 Mar 2013 | 13-1 v BournemouthLeyton Orient 3-1 Bournemouth | npower League One |
| 23 | Wed 6 Mar 2013 | 11-1 v Notts CountyNotts County 1-1 Leyton Orient | npower League One |
| 24 | Sat 9 Mar 2013 | 12-0 v Shrewsbury TownShrewsbury Town 0-2 Leyton Orient | npower League One |
| 25 | Tue 12 Mar 2013 | 11-0 v PortsmouthLeyton Orient 1-0 Portsmouth | npower League One |
| 26 | Sat 16 Mar 2013 | 14-1 v Carlisle UnitedLeyton Orient 4-1 Carlisle United | npower League One |
| 27 | Sat 23 Mar 2013 | 10-0 v Preston North EndPreston North End 0-0 Leyton Orient | npower League One |
| 28 | Fri 29 Mar 2013 | 11-2 v Scunthorpe UnitedScunthorpe United 2-1 Leyton Orient | npower League One |
| 29 | Mon 1 Apr 2013 | 12-0 v BuryLeyton Orient 2-0 Bury | npower League One |
| 30 | Sat 6 Apr 2013 | 11-2 v Colchester UnitedColchester United 2-1 Leyton Orient | npower League One |
| 31 | Sat 13 Apr 2013 | 12-0 v Milton Keynes DonsLeyton Orient 2-0 Milton Keynes Dons | npower League One |
| 32 | Sat 20 Apr 2013 | 11-0 v Coventry CityCoventry City 0-1 Leyton Orient | npower League One |
| 33 | Sat 27 Apr 2013 | 11-1 v Oldham AthleticLeyton Orient 1-1 Oldham Athletic | npower League One |
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