| 1 | Sun 14 Aug 2022 | 24-1 v SV Zulte WaregemSV Zulte Waregem 1-4 KRC Genk | Belgian First Division A |
| 2 | Sat 20 Aug 2022 | 22-1 v Cercle BruggeKRC Genk 2-1 Cercle Brugge | Belgian First Division A |
| 3 | Sat 27 Aug 2022 | 24-0 v SeraingSeraing 0-4 KRC Genk | Belgian First Division A |
| 4 | Sat 3 Sep 2022 | 20-0 v Sint-Truidense VVKRC Genk 0-0 Sint-Truidense VV | Belgian First Division A |
| 5 | Sun 11 Sep 2022 | 22-1 v Union Saint-GilloiseUnion Saint-Gilloise 1-2 KRC Genk | Belgian First Division A |
| 6 | Sun 18 Sep 2022 | 2 1-0 v KAA GentKRC Genk 1-0 KAA Gent | Belgian First Division A |
| 7 | Sat 1 Oct 2022 | 22-1 v KV OostendeKV Oostende 1-2 KRC Genk | Belgian First Division A |
| 8 | Sat 8 Oct 2022 | 22-1 v KV KortrijkKRC Genk 2-1 KV Kortrijk | Belgian First Division A |
| 9 | Sat 15 Oct 2022 | 21-0 v Oud-Heverlee LeuvenOud-Heverlee Leuven 0-1 KRC Genk | Belgian First Division A |
| 10 | Tue 18 Oct 2022 | 26-1 v WesterloKRC Genk 6-1 Westerlo | Belgian First Division A |
| 11 | Sun 23 Oct 2022 | 23-1 v Royal AntwerpRoyal Antwerp 1-3 KRC Genk | Belgian First Division A |
| 12 | Fri 28 Oct 2022 | 23-1 v MechelenKRC Genk 3-1 Mechelen | Belgian First Division A |
| 13 | Fri 4 Nov 2022 | 24-1 v Sporting de CharleroiKRC Genk 4-1 Sporting de Charleroi | Belgian First Division A |
| 14 | Sun 13 Nov 2022 | 2 2-0 v RSC AnderlechtRSC Anderlecht 0-2 KRC Genk | Belgian First Division A |
| 15 | Mon 26 Dec 2022 | 20-1 v KV KortrijkKV Kortrijk 1-0 KRC Genk | Belgian First Division A |
| 16 | Sun 8 Jan 2023 | 23-1 v Club BruggeKRC Genk 3-1 Club Brugge | Belgian First Division A |
| 17 | Sat 14 Jan 2023 | 21-0 v SV Zulte WaregemKRC Genk 1-0 SV Zulte Waregem | Belgian First Division A |
| 18 | Tue 17 Jan 2023 | 23-2 v WesterloWesterlo 2-3 KRC Genk | Belgian First Division A |
| 19 | Sun 29 Jan 2023 | 24-0 v SeraingKRC Genk 4-0 Seraing | Belgian First Division A |
| 20 | Wed 1 Feb 2023 | 21-1 v KAS EupenKAS Eupen 1-1 KRC Genk | Belgian First Division A |
| 21 | Sun 5 Feb 2023 | 23-2 v KAA GentKAA Gent 2-3 KRC Genk | Belgian First Division A |
| 22 | Sun 12 Feb 2023 | 20-1 v Royal AntwerpKRC Genk 0-1 Royal Antwerp | Belgian First Division A |
| 23 | Fri 17 Feb 2023 | 22-2 v MechelenMechelen 2-2 KRC Genk | Belgian First Division A |
| 24 | Sat 25 Feb 2023 | 23-0 v KV OostendeKRC Genk 3-0 KV Oostende | Belgian First Division A |
| 25 | Sun 5 Mar 2023 | 22-2 v Sint-Truidense VVSint-Truidense VV 2-2 KRC Genk | Belgian First Division A |
| 26 | Sun 12 Mar 2023 | 21-2 v Union Saint-GilloiseKRC Genk 1-2 Union Saint-Gilloise | Belgian First Division A |
| 27 | Fri 17 Mar 2023 | 21-1 v Cercle BruggeCercle Brugge 1-1 KRC Genk | Belgian First Division A |
| 28 | Sun 2 Apr 2023 | 2 2-1 v Oud-Heverlee LeuvenKRC Genk 2-1 Oud-Heverlee Leuven | Belgian First Division A |
| 29 | Sun 9 Apr 2023 | 20-2 v Standard LiègeStandard Liège 2-0 KRC Genk | Belgian First Division A |
| 30 | Sun 16 Apr 2023 | 2 5-2 v RSC AnderlechtKRC Genk 5-2 RSC Anderlecht | Belgian First Division A |
| 31 | Sun 23 Apr 2023 | 22-2 v Sporting de CharleroiSporting de Charleroi 2-2 KRC Genk | Belgian First Division A |
| 32 | Sun 30 Apr 2023 | 23-1 v Club BruggeKRC Genk 3-1 Club Brugge | Belgian First Division A Play-off |
| 33 | Sun 7 May 2023 | 21-2 v Royal AntwerpRoyal Antwerp 2-1 KRC Genk | Belgian First Division A Play-off |
| 34 | Sun 14 May 2023 | 2 0-3 v Union Saint-GilloiseUnion Saint-Gilloise 3-0 KRC Genk | Belgian First Division A Play-off |
| 35 | Sun 21 May 2023 | 21-1 v Union Saint-GilloiseKRC Genk 1-1 Union Saint-Gilloise | Belgian First Division A Play-off |
| 36 | Sun 28 May 2023 | 23-1 v Club BruggeClub Brugge 1-3 KRC Genk | Belgian First Division A Play-off |
| 37 | Sun 4 Jun 2023 | 22-2 v Royal AntwerpKRC Genk 2-2 Royal Antwerp | Belgian First Division A Play-off |
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