| 1 | Sat 23 Aug | 440-0 v GenoaGenoa 0-0 Lecce |
| 2 | Fri 29 Aug | 440-2 v AC MilanLecce 0-2 AC Milan |
| 3 | Sun 14 Sep | 441-4 v AtalantaAtalanta 4-1 Lecce |
| 4 | Fri 19 Sep | 44 1-2 v CagliariLecce 1-2 Cagliari |
| 5 | Sun 28 Sep | 442-2 v BolognaLecce 2-2 Bologna |
| 6 | Sat 4 Oct | 441-0 v ParmaParma 0-1 Lecce |
| 7 | Sat 18 Oct | 440-0 v SassuoloLecce 0-0 Sassuolo |
| 8 | Sat 25 Oct | 442-3 v UdineseUdinese 3-2 Lecce |
| 9 | Tue 28 Oct | 440-1 v NapoliLecce 0-1 Napoli |
| 10 | Sun 2 Nov | 441-0 v FiorentinaFiorentina 0-1 Lecce |
| 11 | Sat 8 Nov | 440-0 v Hellas VeronaLecce 0-0 Hellas Verona |
| 12 | Sun 23 Nov | 440-2 v LazioLazio 2-0 Lecce |
| 13 | Sun 30 Nov | 442-1 v TorinoLecce 2-1 Torino |
| 14 | Sun 7 Dec | 440-2 v CremoneseCremonese 2-0 Lecce |
| 15 | Fri 12 Dec | 441-0 v PisaLecce 1-0 Pisa |
| 16 | Sat 27 Dec | 440-3 v Como 1907Lecce 0-3 Como 1907 |
| 17 | Sat 3 Jan | 441-1 v JuventusJuventus 1-1 Lecce |
| 18 | Tue 6 Jan | 440-2 v RomaLecce 0-2 Roma |
| 19 | Sun 11 Jan | 441-2 v ParmaLecce 1-2 Parma |
| 20 | Wed 14 Jan | 440-1 v Inter MilanInter Milan 1-0 Lecce |
| 21 | Sun 18 Jan | 440-1 v AC MilanAC Milan 1-0 Lecce |
| 22 | Sat 24 Jan | 44 0-0 v LazioLecce 0-0 Lazio |
| 23 | Sun 1 Feb | 44 0-1 v TorinoTorino 1-0 Lecce |
| 24 | Sun 8 Feb | 442-1 v UdineseLecce 2-1 Udinese |
| 25 | Mon 16 Feb | 442-0 v CagliariCagliari 0-2 Lecce |
| 26 | Sat 21 Feb | 44 0-2 v Inter MilanLecce 0-2 Inter Milan |
| 27 | Sat 28 Feb | 441-3 v Como 1907Como 1907 3-1 Lecce |
| 28 | Sun 8 Mar | 442-1 v CremoneseLecce 2-1 Cremonese |
| 29 | Sat 14 Mar | 441-2 v NapoliNapoli 2-1 Lecce |
| 30 | Sun 22 Mar | 440-1 v RomaRoma 1-0 Lecce |
| 31 | Mon 6 Apr | 440-3 v AtalantaLecce 0-3 Atalanta |
| 32 | Sun 12 Apr | 440-2 v BolognaBologna 2-0 Lecce |
| 33 | Mon 20 Apr | 44 1-1 v FiorentinaLecce 1-1 Fiorentina |
| 34 | Fri 1 May | 442-1 v PisaPisa 1-2 Lecce |
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