| 1 | Sun 19 Sep 2021 | 163-2 v AZ AlkmaarHeracles Almelo 3-2 AZ Alkmaar | Dutch Eredivisie |
| 2 | Sun 26 Sep 2021 | 161-0 v RKC WaalwijkHeracles Almelo 1-0 RKC Waalwijk | Dutch Eredivisie |
| 3 | Sat 2 Oct 2021 | 163-2 v Willem IIHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 4 | Sat 16 Oct 2021 | 162-4 v Go Ahead EaglesGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 5 | Sat 23 Oct 2021 | 160-1 v PEC ZwollePEC Zwolle 1-0 Heracles Almelo | Dutch Eredivisie |
| 6 | Sat 30 Oct 2021 | 160-0 v AjaxHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 7 | Fri 5 Nov 2021 | 16 0-1 v FC TwenteFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 8 | Sat 20 Nov 2021 | 163-1 v Fortuna SittardHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 9 | Sun 28 Nov 2021 | 160-1 v FC UtrechtFC Utrecht 1-0 Heracles Almelo | Dutch Eredivisie |
| 10 | Wed 1 Dec 2021 | 161-2 v FeyenoordFeyenoord 2-1 Heracles Almelo | Dutch Eredivisie |
| 11 | Sat 4 Dec 2021 | 160-1 v sc HeerenveenHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 12 | Sun 12 Dec 2021 | 161-2 v VitesseVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 13 | Sat 18 Dec 2021 | 164-2 v FC GroningenHeracles Almelo 4-2 FC Groningen | Dutch Eredivisie |
| 14 | Sun 23 Jan 2022 | 161-1 v Go Ahead EaglesHeracles Almelo 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Sun 6 Feb 2022 | 16 0-3 v AjaxAjax 3-0 Heracles Almelo | Dutch Eredivisie |
| 16 | Fri 11 Feb 2022 | 161-0 v FC UtrechtHeracles Almelo 1-0 FC Utrecht | Dutch Eredivisie |
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