| 1 | Fri 5 Nov 2021 | 80-1 v FC TwenteFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 2 | Sat 20 Nov 2021 | 83-1 v Fortuna SittardHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 3 | Sun 28 Nov 2021 | 80-1 v FC UtrechtFC Utrecht 1-0 Heracles Almelo | Dutch Eredivisie |
| 4 | Sat 4 Dec 2021 | 80-1 v sc HeerenveenHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 5 | Sun 12 Dec 2021 | 81-2 v VitesseVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 6 | Sat 18 Dec 2021 | 84-2 v FC GroningenHeracles Almelo 4-2 FC Groningen | Dutch Eredivisie |
| 7 | Sun 23 Jan 2022 | 81-1 v Go Ahead EaglesHeracles Almelo 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 8 | Sun 6 Feb 2022 | 80-3 v AjaxAjax 3-0 Heracles Almelo | Dutch Eredivisie |
| 9 | Fri 11 Feb 2022 | 81-0 v FC UtrechtHeracles Almelo 1-0 FC Utrecht | Dutch Eredivisie |
| 10 | Sat 19 Feb 2022 | 81-2 v AZ AlkmaarAZ Alkmaar 2-1 Heracles Almelo | Dutch Eredivisie |
| 11 | Sat 26 Feb 2022 | 82-0 v PEC ZwolleHeracles Almelo 2-0 PEC Zwolle | Dutch Eredivisie |
| 12 | Sun 6 Mar 2022 | 81-3 v PSV EindhovenPSV Eindhoven 3-1 Heracles Almelo | Dutch Eredivisie |
| 13 | Sun 13 Mar 2022 | 80-0 v VitesseHeracles Almelo 0-0 Vitesse | Dutch Eredivisie |
| 14 | Sun 10 Apr 2022 | 81-4 v FeyenoordHeracles Almelo 1-4 Feyenoord | Dutch Eredivisie |
| 15 | Sat 7 May 2022 | 80-2 v Willem IIWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
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