| 1 | Sat 14 Aug 2021 | 370-2 v PSV EindhovenHeracles Almelo 0-2 PSV Eindhoven | Dutch Eredivisie |
| 2 | Sat 21 Aug 2021 | 371-1 v Sparta RotterdamSparta Rotterdam 1-1 Heracles Almelo | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 370-1 v NEC NijmegenHeracles Almelo 0-1 NEC Nijmegen | Dutch Eredivisie |
| 4 | Sun 19 Sep 2021 | 37 3-2 v AZ AlkmaarHeracles Almelo 3-2 AZ Alkmaar | Dutch Eredivisie |
| 5 | Sun 26 Sep 2021 | 371-0 v RKC WaalwijkHeracles Almelo 1-0 RKC Waalwijk | Dutch Eredivisie |
| 6 | Sat 2 Oct 2021 | 373-2 v Willem IIHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 7 | Sat 16 Oct 2021 | 372-4 v Go Ahead EaglesGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 8 | Sat 23 Oct 2021 | 370-1 v PEC ZwollePEC Zwolle 1-0 Heracles Almelo | Dutch Eredivisie |
| 9 | Sat 30 Oct 2021 | 37 0-0 v AjaxHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 10 | Fri 5 Nov 2021 | 370-1 v FC TwenteFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 11 | Sat 20 Nov 2021 | 37 3-1 v Fortuna SittardHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 12 | Sun 28 Nov 2021 | 370-1 v FC UtrechtFC Utrecht 1-0 Heracles Almelo | Dutch Eredivisie |
| 13 | Wed 1 Dec 2021 | 371-2 v FeyenoordFeyenoord 2-1 Heracles Almelo | Dutch Eredivisie |
| 14 | Sat 4 Dec 2021 | 370-1 v sc HeerenveenHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 15 | Sat 15 Jan 2022 | 370-0 v NEC NijmegenNEC Nijmegen 0-0 Heracles Almelo | Dutch Eredivisie |
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