| 1 | Sun 22 Nov 2020 | 30-5 v AjaxAjax 5-0 Heracles Almelo | Dutch Eredivisie |
| 2 | Sun 29 Nov 2020 | 3 1-2 v AZ AlkmaarHeracles Almelo 1-2 AZ Alkmaar | Dutch Eredivisie |
| 3 | Sun 6 Dec 2020 | 30-0 v FeyenoordFeyenoord 0-0 Heracles Almelo | Dutch Eredivisie |
| 4 | Fri 11 Dec 2020 | 31-2 v Fortuna SittardHeracles Almelo 1-2 Fortuna Sittard | Dutch Eredivisie |
| 5 | Sun 20 Dec 2020 | 32-1 v sc Heerenveensc Heerenveen 1-2 Heracles Almelo | Dutch Eredivisie |
| 6 | Wed 23 Dec 2020 | 31-0 v FC GroningenFC Groningen 0-1 Heracles Almelo | Dutch Eredivisie |
| 7 | Sat 9 Jan 2021 | 30-2 v VitesseHeracles Almelo 0-2 Vitesse | Dutch Eredivisie |
| 8 | Tue 12 Jan 2021 | 34-0 v FC EmmenHeracles Almelo 4-0 FC Emmen | Dutch Eredivisie |
| 9 | Sat 16 Jan 2021 | 30-2 v FC UtrechtFC Utrecht 2-0 Heracles Almelo | Dutch Eredivisie |
| 10 | Sat 23 Jan 2021 | 3 1-0 v sc HeerenveenHeracles Almelo 1-0 sc Heerenveen | Dutch Eredivisie |
| 11 | Tue 26 Jan 2021 | 3 2-2 v PEC ZwollePEC Zwolle 2-2 Heracles Almelo | Dutch Eredivisie |
| 12 | Sat 30 Jan 2021 | 31-0 v FC GroningenHeracles Almelo 1-0 FC Groningen | Dutch Eredivisie |
| 13 | Fri 5 Feb 2021 | 3 1-0 v Fortuna SittardFortuna Sittard 0-1 Heracles Almelo | Dutch Eredivisie |
| 14 | Sat 13 Feb 2021 | 3 0-2 v AjaxHeracles Almelo 0-2 Ajax | Dutch Eredivisie |
| 15 | Sat 27 Feb 2021 | 32-2 v FC TwenteHeracles Almelo 2-2 FC Twente | Dutch Eredivisie |
| 16 | Sun 7 Mar 2021 | 32-1 v PEC ZwolleHeracles Almelo 2-1 PEC Zwolle | Dutch Eredivisie |
| 17 | Sat 13 Mar 2021 | 32-1 v ADO Den HaagADO Den Haag 1-2 Heracles Almelo | Dutch Eredivisie |
| 18 | Sun 21 Mar 2021 | 31-1 v Sparta RotterdamHeracles Almelo 1-1 Sparta Rotterdam | Dutch Eredivisie |
| 19 | Sun 4 Apr 2021 | 3 0-3 v PSV EindhovenPSV Eindhoven 3-0 Heracles Almelo | Dutch Eredivisie |
| 20 | Sat 10 Apr 2021 | 34-0 v Willem IIHeracles Almelo 4-0 Willem II | Dutch Eredivisie |
| 21 | Sun 25 Apr 2021 | 31-3 v FC EmmenFC Emmen 3-1 Heracles Almelo | Dutch Eredivisie |
| 22 | Sat 1 May 2021 | 34-0 v VVV VenloHeracles Almelo 4-0 VVV Venlo | Dutch Eredivisie |
| 23 | Sat 8 May 2021 | 31-1 v FC TwenteFC Twente 1-1 Heracles Almelo | Dutch Eredivisie |
| 24 | Thu 13 May 2021 | 3 1-1 v FeyenoordHeracles Almelo 1-1 Feyenoord | Dutch Eredivisie |
| 25 | Sun 16 May 2021 | 30-5 v AZ AlkmaarAZ Alkmaar 5-0 Heracles Almelo | Dutch Eredivisie |
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