| 1 | Sat 30 Jul 2022 | 270-2 v Leyton OrientLeyton Orient 2-0 Grimsby Town | Sky Bet League Two |
| 2 | Sat 6 Aug 2022 | 271-1 v Northampton TownGrimsby Town 1-1 Northampton Town | Sky Bet League Two |
| 3 | Tue 9 Aug 2022 | 274-0 v Crewe AlexandraGrimsby Town 4-0 Crewe Alexandra | Carabao Cup First Round |
| 4 | Sat 13 Aug 2022 | 271-0 v RochdaleRochdale 0-1 Grimsby Town | Sky Bet League Two |
| 5 | Sat 20 Aug 2022 | 270-0 v Sutton UnitedGrimsby Town 0-0 Sutton United | Sky Bet League Two |
| 6 | Tue 23 Aug 2022 | 270-3 v Nottingham ForestGrimsby Town 0-3 Nottingham Forest | Carabao Cup Second Round |
| 7 | Tue 30 Aug 2022 | 271-3 v Derby CountyDerby County 3-1 Grimsby Town | Papa John’s Trophy |
| 8 | Sat 3 Sep 2022 | 27 2-0 v Newport CountyNewport County 0-2 Grimsby Town | Sky Bet League Two |
| 9 | Tue 13 Sep 2022 | 271-1 v GillinghamGrimsby Town 1-1 Gillingham | Sky Bet League Two |
| 10 | Sat 17 Sep 2022 | 27 1-0 v Colchester UnitedColchester United 0-1 Grimsby Town | Sky Bet League Two |
| 11 | Sat 24 Sep 2022 | 271-2 v Swindon TownGrimsby Town 1-2 Swindon Town | Sky Bet League Two |
| 12 | Sat 1 Oct 2022 | 271-1 v Salford CitySalford City 1-1 Grimsby Town | Sky Bet League Two |
| 13 | Sat 8 Oct 2022 | 27 3-0 v Crawley TownGrimsby Town 3-0 Crawley Town | Sky Bet League Two |
| 14 | Sat 15 Oct 2022 | 273-1 v Stockport CountyStockport County 1-3 Grimsby Town | Sky Bet League Two |
| 15 | Sat 22 Oct 2022 | 27 0-0 v Bradford CityGrimsby Town 0-0 Bradford City | Sky Bet League Two |
| 16 | Sat 5 Nov 2022 | 275-1 v Plymouth ArgyleGrimsby Town 5-1 Plymouth Argyle | Emirates FA Cup First Round |
| 17 | Sat 12 Nov 2022 | 271-3 v Doncaster RoversGrimsby Town 1-3 Doncaster Rovers | Sky Bet League Two |
| 18 | Sat 19 Nov 2022 | 271-1 v StevenageGrimsby Town 1-1 Stevenage | Sky Bet League Two |
| 19 | Tue 22 Nov 2022 | 270-1 v Accrington StanleyGrimsby Town 0-1 Accrington Stanley | Papa John’s Trophy Second Round |
| 20 | Sat 26 Nov 2022 | 272-1 v Cambridge UnitedCambridge United 1-2 Grimsby Town | Emirates FA Cup Second Round |
| 21 | Sat 3 Dec 2022 | 270-1 v AFC WimbledonAFC Wimbledon 1-0 Grimsby Town | Sky Bet League Two |
| 22 | Sat 10 Dec 2022 | 272-1 v Tranmere RoversGrimsby Town 2-1 Tranmere Rovers | Sky Bet League Two |
| 23 | Mon 26 Dec 2022 | 272-3 v Harrogate TownHarrogate Town 3-2 Grimsby Town | Sky Bet League Two |
| 24 | Thu 29 Dec 2022 | 271-4 v Salford CityGrimsby Town 1-4 Salford City | Sky Bet League Two |
| 25 | Sun 1 Jan 2023 | 271-0 v Stockport CountyGrimsby Town 1-0 Stockport County | Sky Bet League Two |
| 26 | Sat 7 Jan 2023 | 271-0 v Burton AlbionGrimsby Town 1-0 Burton Albion | Emirates FA Cup Third Round |
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