| 1 | Sat 6 Feb 2021 | 210-1 v Newport CountyNewport County 1-0 Grimsby Town | Sky Bet League Two |
| 2 | Tue 23 Feb 2021 | 212-1 v Crawley TownGrimsby Town 2-1 Crawley Town | Sky Bet League Two |
| 3 | Sat 27 Feb 2021 | 210-1 v Harrogate TownHarrogate Town 1-0 Grimsby Town | Sky Bet League Two |
| 4 | Tue 2 Mar 2021 | 210-1 v Leyton OrientGrimsby Town 0-1 Leyton Orient | Sky Bet League Two |
| 5 | Sat 6 Mar 2021 | 211-2 v Forest Green RoversGrimsby Town 1-2 Forest Green Rovers | Sky Bet League Two |
| 6 | Tue 9 Mar 2021 | 211-1 v Carlisle UnitedCarlisle United 1-1 Grimsby Town | Sky Bet League Two |
| 7 | Sat 13 Mar 2021 | 210-0 v Colchester UnitedGrimsby Town 0-0 Colchester United | Sky Bet League Two |
| 8 | Wed 17 Mar 2021 | 210-0 v Tranmere RoversGrimsby Town 0-0 Tranmere Rovers | Sky Bet League Two |
| 9 | Sat 20 Mar 2021 | 212-2 v Mansfield TownMansfield Town 2-2 Grimsby Town | Sky Bet League Two |
| 10 | Tue 23 Mar 2021 | 21 1-0 v BarrowBarrow 0-1 Grimsby Town | Sky Bet League Two |
| 11 | Sat 27 Mar 2021 | 211-1 v WalsallGrimsby Town 1-1 Walsall | Sky Bet League Two |
| 12 | Fri 2 Apr 2021 | 211-1 v Salford CitySalford City 1-1 Grimsby Town | Sky Bet League Two |
| 13 | Mon 5 Apr 2021 | 211-1 v Cheltenham TownGrimsby Town 1-1 Cheltenham Town | Sky Bet League Two |
| 14 | Sat 10 Apr 2021 | 210-1 v Bradford CityBradford City 1-0 Grimsby Town | Sky Bet League Two |
| 15 | Sat 17 Apr 2021 | 212-1 v Bolton WanderersGrimsby Town 2-1 Bolton Wanderers | Sky Bet League Two |
| 16 | Tue 20 Apr 2021 | 210-3 v MorecambeGrimsby Town 0-3 Morecambe | Sky Bet League Two |
| 17 | Sat 24 Apr 2021 | 212-1 v Oldham AthleticOldham Athletic 1-2 Grimsby Town | Sky Bet League Two |
| 18 | Tue 27 Apr 2021 | 212-3 v Exeter CityExeter City 3-2 Grimsby Town | Sky Bet League Two |
| 19 | Sat 1 May 2021 | 211-0 v Port ValeGrimsby Town 1-0 Port Vale | Sky Bet League Two |
| 20 | Sat 8 May 2021 | 210-3 v Cambridge UnitedCambridge United 3-0 Grimsby Town | Sky Bet League Two |
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