| 1 | Sat 5 Sep 2020 | 31-1 v MorecambeGrimsby Town 1-1 Morecambe | Carabao Cup First Round North |
| 2 | Sat 19 Sep 2020 | 30-4 v Salford CityGrimsby Town 0-4 Salford City | Sky Bet League Two |
| 3 | Sat 10 Oct 2020 | 30-0 v Bolton WanderersBolton Wanderers 0-0 Grimsby Town | Sky Bet League Two |
| 4 | Tue 13 Oct 2020 | 33-1 v Cheltenham TownCheltenham Town 1-3 Grimsby Town | Sky Bet League Two |
| 5 | Sat 17 Oct 2020 | 33-2 v Leyton OrientLeyton Orient 2-3 Grimsby Town | Sky Bet League Two |
| 6 | Tue 20 Oct 2020 | 3 1-2 v Harrogate TownGrimsby Town 1-2 Harrogate Town | Sky Bet League Two |
| 7 | Sat 24 Oct 2020 | 31-1 v Carlisle UnitedGrimsby Town 1-1 Carlisle United | Sky Bet League Two |
| 8 | Tue 27 Oct 2020 | 30-1 v Forest Green RoversForest Green Rovers 1-0 Grimsby Town | Sky Bet League Two |
| 9 | Sat 31 Oct 2020 | 30-0 v StevenageStevenage 0-0 Grimsby Town | Sky Bet League Two |
| 10 | Tue 3 Nov 2020 | 31-0 v BarrowGrimsby Town 1-0 Barrow | Sky Bet League Two |
| 11 | Tue 17 Nov 2020 | 30-3 v Hull CityHull City 3-0 Grimsby Town | Papa John’s Trophy Group 10 |
| 12 | Sat 21 Nov 2020 | 30-5 v Tranmere RoversTranmere Rovers 5-0 Grimsby Town | Sky Bet League Two |
| 13 | Tue 24 Nov 2020 | 32-1 v Crawley TownCrawley Town 1-2 Grimsby Town | Sky Bet League Two |
| 14 | Tue 1 Dec 2020 | 31-4 v Exeter CityGrimsby Town 1-4 Exeter City | Sky Bet League Two |
| 15 | Sat 5 Dec 2020 | 31-2 v Colchester UnitedColchester United 2-1 Grimsby Town | Sky Bet League Two |
| 16 | Sat 12 Dec 2020 | 31-1 v Mansfield TownGrimsby Town 1-1 Mansfield Town | Sky Bet League Two |
| 17 | Tue 15 Dec 2020 | 31-3 v Southend UnitedSouthend United 3-1 Grimsby Town | Sky Bet League Two |
| 18 | Sat 19 Dec 2020 | 31-0 v Scunthorpe UnitedGrimsby Town 1-0 Scunthorpe United | Sky Bet League Two |
| 19 | Tue 22 Dec 2020 | 31-2 v Bradford CityGrimsby Town 1-2 Bradford City | Sky Bet League Two |
| 20 | Sat 26 Dec 2020 | 31-3 v MorecambeMorecambe 3-1 Grimsby Town | Sky Bet League Two |
| 21 | Tue 29 Dec 2020 | 3 0-0 v Oldham AthleticGrimsby Town 0-0 Oldham Athletic | Sky Bet League Two |
| 22 | Sat 2 Jan 2021 | 31-2 v Cambridge UnitedGrimsby Town 1-2 Cambridge United | Sky Bet League Two |
| 23 | Sat 9 Jan 2021 | 30-3 v Port ValePort Vale 3-0 Grimsby Town | Sky Bet League Two |
| 24 | Sat 16 Jan 2021 | 30-0 v Southend UnitedGrimsby Town 0-0 Southend United | Sky Bet League Two |
| 25 | Sat 23 Jan 2021 | 30-3 v Scunthorpe UnitedScunthorpe United 3-0 Grimsby Town | Sky Bet League Two |
| 26 | Sat 30 Jan 2021 | 31-2 v StevenageGrimsby Town 1-2 Stevenage | Sky Bet League Two |
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