| 1 | Mon 16 Aug 2021 | 40-0 v VillarrealVillarreal 0-0 Granada | Spanish La Liga |
| 2 | Sat 21 Aug 2021 | 4 1-1 v ValenciaGranada 1-1 Valencia | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 40-4 v Rayo VallecanoRayo Vallecano 4-0 Granada | Spanish La Liga |
| 4 | Mon 13 Sep 2021 | 4 1-2 v Real BetisGranada 1-2 Real Betis | Spanish La Liga |
| 5 | Mon 20 Sep 2021 | 4 1-1 v BarcelonaBarcelona 1-1 Granada | Spanish La Liga |
| 6 | Thu 23 Sep 2021 | 42-3 v Real SociedadGranada 2-3 Real Sociedad | Spanish La Liga |
| 7 | Mon 27 Sep 2021 | 40-1 v Celta VigoCelta Vigo 1-0 Granada | Spanish La Liga |
| 8 | Sun 3 Oct 2021 | 4 1-0 v SevillaGranada 1-0 Sevilla | Spanish La Liga |
| 9 | Fri 22 Oct 2021 | 41-1 v OsasunaOsasuna 1-1 Granada | Spanish La Liga |
| 10 | Sun 21 Nov 2021 | 41-4 v Real MadridGranada 1-4 Real Madrid | Spanish La Liga |
| 11 | Fri 26 Nov 2021 | 42-2 v Athletic BilbaoAthletic Bilbao 2-2 Granada | Spanish La Liga |
| 12 | Fri 3 Dec 2021 | 42-1 v AlavésGranada 2-1 Alavés | Spanish La Liga |
| 13 | Mon 13 Dec 2021 | 41-1 v CádizCádiz 1-1 Granada | Spanish La Liga |
| 14 | Sun 19 Dec 2021 | 4 4-1 v MallorcaGranada 4-1 Mallorca | Spanish La Liga |
| 15 | Sun 2 Jan 2022 | 40-0 v ElcheElche 0-0 Granada | Spanish La Liga |
| 16 | Sat 8 Jan 2022 | 4 1-1 v BarcelonaGranada 1-1 Barcelona | Spanish La Liga |
| 17 | Sun 23 Jan 2022 | 40-2 v OsasunaGranada 0-2 Osasuna | Spanish La Liga |
| 18 | Sun 6 Feb 2022 | 40-1 v Real MadridReal Madrid 1-0 Granada | Spanish La Liga |
| 19 | Sun 13 Feb 2022 | 40-2 v Real SociedadReal Sociedad 2-0 Granada | Spanish La Liga |
| 20 | Sat 19 Feb 2022 | 41-4 v VillarrealGranada 1-4 Villarreal | Spanish La Liga |
| 21 | Sun 1 May 2022 | 41-1 v Celta VigoGranada 1-1 Celta Vigo | Spanish La Liga |
| 22 | Sat 7 May 2022 | 46-2 v MallorcaMallorca 2-6 Granada | Spanish La Liga |
| 23 | Tue 10 May 2022 | 41-0 v Athletic BilbaoGranada 1-0 Athletic Bilbao | Spanish La Liga |
| 24 | Sun 15 May 2022 | 40-2 v Real BetisReal Betis 2-0 Granada | Spanish La Liga |
| 25 | Sun 22 May 2022 | 40-0 v EspanyolGranada 0-0 Espanyol | Spanish La Liga |
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