| 1 | Mon 13 Sep 2021 | 11-2 v Real BetisGranada 1-2 Real Betis | Spanish La Liga |
| 2 | Mon 20 Sep 2021 | 1 1-1 v BarcelonaBarcelona 1-1 Granada | Spanish La Liga |
| 3 | Thu 23 Sep 2021 | 12-3 v Real SociedadGranada 2-3 Real Sociedad | Spanish La Liga |
| 4 | Mon 27 Sep 2021 | 10-1 v Celta VigoCelta Vigo 1-0 Granada | Spanish La Liga |
| 5 | Sun 3 Oct 2021 | 11-0 v SevillaGranada 1-0 Sevilla | Spanish La Liga |
| 6 | Fri 22 Oct 2021 | 11-1 v OsasunaOsasuna 1-1 Granada | Spanish La Liga |
| 7 | Thu 28 Oct 2021 | 11-1 v GetafeGranada 1-1 Getafe | Spanish La Liga |
| 8 | Mon 1 Nov 2021 | 13-0 v LevanteLevante 0-3 Granada | Spanish La Liga |
| 9 | Sat 6 Nov 2021 | 10-2 v EspanyolEspanyol 2-0 Granada | Spanish La Liga |
| 10 | Sun 21 Nov 2021 | 11-4 v Real MadridGranada 1-4 Real Madrid | Spanish La Liga |
| 11 | Fri 26 Nov 2021 | 12-2 v Athletic BilbaoAthletic Bilbao 2-2 Granada | Spanish La Liga |
| 12 | Fri 3 Dec 2021 | 12-1 v AlavésGranada 2-1 Alavés | Spanish La Liga |
| 13 | Mon 13 Dec 2021 | 11-1 v CádizCádiz 1-1 Granada | Spanish La Liga |
| 14 | Sun 19 Dec 2021 | 14-1 v MallorcaGranada 4-1 Mallorca | Spanish La Liga |
| 15 | Wed 22 Dec 2021 | 1 2-1 v Atlético MadridGranada 2-1 Atlético Madrid | Spanish La Liga |
| 16 | Sun 2 Jan 2022 | 10-0 v ElcheElche 0-0 Granada | Spanish La Liga |
| 17 | Sat 8 Jan 2022 | 11-1 v BarcelonaGranada 1-1 Barcelona | Spanish La Liga |
| 18 | Thu 20 Jan 2022 | 12-4 v GetafeGetafe 4-2 Granada | Spanish La Liga |
| 19 | Sun 23 Jan 2022 | 10-2 v OsasunaGranada 0-2 Osasuna | Spanish La Liga |
| 20 | Sun 6 Feb 2022 | 10-1 v Real MadridReal Madrid 1-0 Granada | Spanish La Liga |
| 21 | Sun 13 Feb 2022 | 10-2 v Real SociedadReal Sociedad 2-0 Granada | Spanish La Liga |
| 22 | Sat 19 Feb 2022 | 11-4 v VillarrealGranada 1-4 Villarreal | Spanish La Liga |
| 23 | Mon 28 Feb 2022 | 10-0 v CádizGranada 0-0 Cádiz | Spanish La Liga |
| 24 | Sat 5 Mar 2022 | 11-3 v ValenciaValencia 3-1 Granada | Spanish La Liga |
| 25 | Sat 12 Mar 2022 | 10-1 v ElcheGranada 0-1 Elche | Spanish La Liga |
| 26 | Sat 19 Mar 2022 | 13-2 v AlavésAlavés 2-3 Granada | Spanish La Liga |
| 27 | Sun 3 Apr 2022 | 12-2 v Rayo VallecanoGranada 2-2 Rayo Vallecano | Spanish La Liga |
| 28 | Fri 8 Apr 2022 | 12-4 v SevillaSevilla 4-2 Granada | Spanish La Liga |
| 29 | Sun 17 Apr 2022 | 11-4 v LevanteGranada 1-4 Levante | Spanish La Liga |
| 30 | Wed 20 Apr 2022 | 10-0 v Atlético MadridAtlético Madrid 0-0 Granada | Spanish La Liga |
| 31 | Sun 1 May 2022 | 11-1 v Celta VigoGranada 1-1 Celta Vigo | Spanish La Liga |
| 32 | Sat 7 May 2022 | 16-2 v MallorcaMallorca 2-6 Granada | Spanish La Liga |
| 33 | Tue 10 May 2022 | 11-0 v Athletic BilbaoGranada 1-0 Athletic Bilbao | Spanish La Liga |
| 34 | Sun 15 May 2022 | 10-2 v Real BetisReal Betis 2-0 Granada | Spanish La Liga |
| 35 | Sun 22 May 2022 | 10-0 v EspanyolGranada 0-0 Espanyol | Spanish La Liga |
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