| 1 | Sat 28 Aug 2021 | 62-0 v Sparta RotterdamGo Ahead Eagles 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 2 | Sat 2 Oct 2021 | 6 1-1 v RKC WaalwijkRKC Waalwijk 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 3 | Sat 16 Oct 2021 | 64-2 v Heracles AlmeloGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 4 | Sun 24 Oct 2021 | 62-1 v VitesseVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 5 | Sat 27 Nov 2021 | 61-0 v Willem IIWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 6 | Sun 5 Dec 2021 | 61-2 v FC TwenteGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 7 | Sat 11 Dec 2021 | 60-0 v FC UtrechtFC Utrecht 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 8 | Sun 19 Dec 2021 | 60-2 v NEC NijmegenGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 9 | Thu 23 Dec 2021 | 60-2 v PSV EindhovenPSV Eindhoven 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Sat 15 Jan 2022 | 60-2 v RKC WaalwijkGo Ahead Eagles 0-2 RKC Waalwijk | Dutch Eredivisie |
| 11 | Sun 23 Jan 2022 | 61-1 v Heracles AlmeloHeracles Almelo 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 12 | Sun 6 Feb 2022 | 61-2 v FC GroningenFC Groningen 2-1 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Sun 13 Feb 2022 | 61-4 v AZ AlkmaarGo Ahead Eagles 1-4 AZ Alkmaar | Dutch Eredivisie |
| 14 | Sun 20 Feb 2022 | 62-2 v FC TwenteFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Sun 27 Feb 2022 | 62-1 v AjaxGo Ahead Eagles 2-1 Ajax | Dutch Eredivisie |
| 16 | Sat 5 Mar 2022 | 61-1 v FC UtrechtGo Ahead Eagles 1-1 FC Utrecht | Dutch Eredivisie |
| 17 | Sat 12 Mar 2022 | 6 0-1 v Sparta RotterdamSparta Rotterdam 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 18 | Sun 3 Apr 2022 | 61-0 v PEC ZwollePEC Zwolle 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 19 | Sun 8 May 2022 | 60-1 v NEC NijmegenNEC Nijmegen 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 20 | Wed 11 May 2022 | 60-1 v FeyenoordGo Ahead Eagles 0-1 Feyenoord | Dutch Eredivisie |
| 21 | Sun 15 May 2022 | 61-3 v sc Heerenveensc Heerenveen 3-1 Go Ahead Eagles | Dutch Eredivisie |
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