| 1 | Fri 22 Aug | 240-6 v Bayern MunichBayern Munich 6-0 RB Leipzig |
| 2 | Sat 30 Aug | 242-0 v 1 FC HeidenheimRB Leipzig 2-0 1 FC Heidenheim |
| 3 | Sat 13 Sep | 241-0 v Mainz 05Mainz 05 0-1 RB Leipzig |
| 4 | Sat 18 Oct | 242-1 v Hamburger SVRB Leipzig 2-1 Hamburger SV |
| 5 | Sat 25 Oct | 24 6-0 v FC AugsburgFC Augsburg 0-6 RB Leipzig |
| 6 | Sat 1 Nov | 243-1 v VfB StuttgartRB Leipzig 3-1 VfB Stuttgart |
| 7 | Sun 23 Nov | 242-0 v Werder BremenRB Leipzig 2-0 Werder Bremen |
| 8 | Fri 28 Nov | 24 0-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-0 RB Leipzig |
| 9 | Sat 6 Dec | 246-0 v Eintracht FrankfurtRB Leipzig 6-0 Eintracht Frankfurt |
| 10 | Fri 12 Dec | 241-3 v Union BerlinUnion Berlin 3-1 RB Leipzig |
| 11 | Sat 20 Dec | 241-3 v Bayer LeverkusenRB Leipzig 1-3 Bayer Leverkusen |
| 12 | Wed 14 Jan | 242-0 v SC FreiburgRB Leipzig 2-0 SC Freiburg |
| 13 | Sat 17 Jan | 241-5 v Bayern MunichRB Leipzig 1-5 Bayern Munich |
| 14 | Sat 24 Jan | 243-0 v 1 FC Heidenheim1 FC Heidenheim 0-3 RB Leipzig |
| 15 | Tue 27 Jan | 241-1 v FC St PauliFC St Pauli 1-1 RB Leipzig |
| 16 | Sat 31 Jan | 241-2 v Mainz 05RB Leipzig 1-2 Mainz 05 |
| 17 | Sun 8 Feb | 242-1 v 1 FC Köln1 FC Köln 1-2 RB Leipzig |
| 18 | Sun 15 Feb | 24 2-2 v VfL WolfsburgRB Leipzig 2-2 VfL Wolfsburg |
| 19 | Sat 21 Feb | 242-2 v Borussia DortmundRB Leipzig 2-2 Borussia Dortmund |
| 20 | Sun 15 Mar | 24 0-1 v VfB StuttgartVfB Stuttgart 1-0 RB Leipzig |
| 21 | Fri 20 Mar | 245-0 v TSG HoffenheimRB Leipzig 5-0 TSG Hoffenheim |
| 22 | Sat 4 Apr | 242-1 v Werder BremenWerder Bremen 1-2 RB Leipzig |
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