| 1 | Fri 22 Aug | 4 0-6 v Bayern MunichBayern Munich 6-0 RB Leipzig |
| 2 | Sat 30 Aug | 42-0 v 1 FC HeidenheimRB Leipzig 2-0 1 FC Heidenheim |
| 3 | Sat 13 Sep | 41-0 v Mainz 05Mainz 05 0-1 RB Leipzig |
| 4 | Sat 20 Sep | 43-1 v 1 FC KölnRB Leipzig 3-1 1 FC Köln |
| 5 | Sat 27 Sep | 4 1-0 v VfL WolfsburgVfL Wolfsburg 0-1 RB Leipzig |
| 6 | Sat 4 Oct | 41-1 v Borussia DortmundBorussia Dortmund 1-1 RB Leipzig |
| 7 | Sat 18 Oct | 42-1 v Hamburger SVRB Leipzig 2-1 Hamburger SV |
| 8 | Sat 25 Oct | 46-0 v FC AugsburgFC Augsburg 0-6 RB Leipzig |
| 9 | Sat 1 Nov | 43-1 v VfB StuttgartRB Leipzig 3-1 VfB Stuttgart |
| 10 | Sat 8 Nov | 41-3 v TSG HoffenheimTSG Hoffenheim 3-1 RB Leipzig |
| 11 | Sun 23 Nov | 42-0 v Werder BremenRB Leipzig 2-0 Werder Bremen |
| 12 | Fri 28 Nov | 40-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-0 RB Leipzig |
| 13 | Sat 6 Dec | 46-0 v Eintracht FrankfurtRB Leipzig 6-0 Eintracht Frankfurt |
| 14 | Fri 12 Dec | 41-3 v Union BerlinUnion Berlin 3-1 RB Leipzig |
| 15 | Sat 20 Dec | 41-3 v Bayer LeverkusenRB Leipzig 1-3 Bayer Leverkusen |
| 16 | Wed 14 Jan | 42-0 v SC FreiburgRB Leipzig 2-0 SC Freiburg |
| 17 | Sat 17 Jan | 41-5 v Bayern MunichRB Leipzig 1-5 Bayern Munich |
| 18 | Sat 24 Jan | 43-0 v 1 FC Heidenheim1 FC Heidenheim 0-3 RB Leipzig |
| 19 | Tue 27 Jan | 41-1 v FC St PauliFC St Pauli 1-1 RB Leipzig |
| 20 | Sat 31 Jan | 41-2 v Mainz 05RB Leipzig 1-2 Mainz 05 |
| 21 | Sun 8 Feb | 42-1 v 1 FC Köln1 FC Köln 1-2 RB Leipzig |
| 22 | Sun 15 Feb | 42-2 v VfL WolfsburgRB Leipzig 2-2 VfL Wolfsburg |
| 23 | Sat 21 Feb | 42-2 v Borussia DortmundRB Leipzig 2-2 Borussia Dortmund |
| 24 | Sun 1 Mar | 4 2-1 v Hamburger SVHamburger SV 1-2 RB Leipzig |
| 25 | Sat 7 Mar | 42-1 v FC AugsburgRB Leipzig 2-1 FC Augsburg |
| 26 | Sun 15 Mar | 40-1 v VfB StuttgartVfB Stuttgart 1-0 RB Leipzig |
| 27 | Fri 20 Mar | 4 5-0 v TSG HoffenheimRB Leipzig 5-0 TSG Hoffenheim |
| 28 | Sat 4 Apr | 42-1 v Werder BremenWerder Bremen 1-2 RB Leipzig |
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