| 1 | Sat 23 Aug | 342-1 v Bayer LeverkusenBayer Leverkusen 1-2 TSG Hoffenheim |
| 2 | Sat 30 Aug | 341-3 v Eintracht FrankfurtTSG Hoffenheim 1-3 Eintracht Frankfurt |
| 3 | Sat 13 Sep | 344-2 v Union BerlinUnion Berlin 2-4 TSG Hoffenheim |
| 4 | Sat 20 Sep | 34 1-4 v Bayern MunichTSG Hoffenheim 1-4 Bayern Munich |
| 5 | Sun 28 Sep | 341-1 v SC FreiburgSC Freiburg 1-1 TSG Hoffenheim |
| 6 | Fri 3 Oct | 340-1 v 1 FC KölnTSG Hoffenheim 0-1 1 FC Köln |
| 7 | Sun 19 Oct | 343-0 v FC St PauliFC St Pauli 0-3 TSG Hoffenheim |
| 8 | Sat 25 Oct | 343-1 v 1 FC HeidenheimTSG Hoffenheim 3-1 1 FC Heidenheim |
| 9 | Sun 2 Nov | 343-2 v VfL WolfsburgVfL Wolfsburg 2-3 TSG Hoffenheim |
| 10 | Sat 8 Nov | 343-1 v RB LeipzigTSG Hoffenheim 3-1 RB Leipzig |
| 11 | Fri 21 Nov | 341-1 v Mainz 05Mainz 05 1-1 TSG Hoffenheim |
| 12 | Sat 29 Nov | 343-0 v FC AugsburgTSG Hoffenheim 3-0 FC Augsburg |
| 13 | Sun 7 Dec | 340-2 v Borussia DortmundBorussia Dortmund 2-0 TSG Hoffenheim |
| 14 | Sat 13 Dec | 344-1 v Hamburger SVTSG Hoffenheim 4-1 Hamburger SV |
| 15 | Sat 20 Dec | 340-0 v VfB StuttgartVfB Stuttgart 0-0 TSG Hoffenheim |
| 16 | Wed 14 Jan | 345-1 v Borussia MönchengladbachTSG Hoffenheim 5-1 Borussia Mönchengladbach |
| 17 | Sat 17 Jan | 341-0 v Bayer LeverkusenTSG Hoffenheim 1-0 Bayer Leverkusen |
| 18 | Sat 24 Jan | 34 3-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 TSG Hoffenheim |
| 19 | Tue 27 Jan | 342-0 v Werder BremenWerder Bremen 0-2 TSG Hoffenheim |
| 20 | Sat 31 Jan | 343-1 v Union BerlinTSG Hoffenheim 3-1 Union Berlin |
| 21 | Sun 8 Feb | 341-5 v Bayern MunichBayern Munich 5-1 TSG Hoffenheim |
| 22 | Sat 14 Feb | 343-0 v SC FreiburgTSG Hoffenheim 3-0 SC Freiburg |
| 23 | Sat 21 Feb | 34 2-2 v 1 FC Köln1 FC Köln 2-2 TSG Hoffenheim |
| 24 | Sat 28 Feb | 340-1 v FC St PauliTSG Hoffenheim 0-1 FC St Pauli |
| 25 | Sat 7 Mar | 344-2 v 1 FC Heidenheim1 FC Heidenheim 2-4 TSG Hoffenheim |
| 26 | Sat 14 Mar | 341-1 v VfL WolfsburgTSG Hoffenheim 1-1 VfL Wolfsburg |
| 27 | Fri 20 Mar | 340-5 v RB LeipzigRB Leipzig 5-0 TSG Hoffenheim |
| 28 | Sat 4 Apr | 34 1-2 v Mainz 05TSG Hoffenheim 1-2 Mainz 05 |
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