| 1 | Sat 14 Sep | 71-4 v Bayer 04 Leverkusen1899 Hoffenheim 1-4 Bayer 04 Leverkusen |
| 2 | Sat 21 Sep | 7 1-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 1899 Hoffenheim |
| 3 | Sun 29 Sep | 73-4 v Werder Bremen1899 Hoffenheim 3-4 Werder Bremen |
| 4 | Sun 6 Oct | 7 1-1 v VfB StuttgartVfB Stuttgart 1-1 1899 Hoffenheim |
| 5 | Sat 19 Oct | 73-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum |
| 6 | Sun 27 Oct | 70-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 1899 Hoffenheim |
| 7 | Sat 2 Nov | 70-2 v FC St Pauli1899 Hoffenheim 0-2 FC St Pauli |
| 8 | Sun 10 Nov | 70-0 v FC AugsburgFC Augsburg 0-0 1899 Hoffenheim |
| 9 | Sat 23 Nov | 74-3 v RB Leipzig1899 Hoffenheim 4-3 RB Leipzig |
| 10 | Sun 1 Dec | 70-2 v Mainz 05Mainz 05 2-0 1899 Hoffenheim |
| 11 | Sun 8 Dec | 71-1 v SC Freiburg1899 Hoffenheim 1-1 SC Freiburg |
| 12 | Sun 15 Dec | 71-1 v Borussia DortmundBorussia Dortmund 1-1 1899 Hoffenheim |
| 13 | Sat 21 Dec | 71-2 v Borussia Mönchengladbach1899 Hoffenheim 1-2 Borussia Mönchengladbach |
| 14 | Sat 11 Jan | 70-1 v VfL Wolfsburg1899 Hoffenheim 0-1 VfL Wolfsburg |
| 15 | Wed 15 Jan | 70-5 v Bayern MunichBayern Munich 5-0 1899 Hoffenheim |
| 16 | Sat 18 Jan | 73-1 v Holstein KielHolstein Kiel 1-3 1899 Hoffenheim |
| 17 | Sun 26 Jan | 72-2 v Eintracht Frankfurt1899 Hoffenheim 2-2 Eintracht Frankfurt |
| 18 | Sun 2 Feb | 7 1-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-1 1899 Hoffenheim |
| 19 | Sat 8 Feb | 70-4 v 1 FC Union Berlin1899 Hoffenheim 0-4 1 FC Union Berlin |
| 20 | Sun 16 Feb | 73-1 v Werder BremenWerder Bremen 1-3 1899 Hoffenheim |
| 21 | Sun 23 Feb | 71-1 v VfB Stuttgart1899 Hoffenheim 1-1 VfB Stuttgart |
| 22 | Sat 1 Mar | 71-0 v VfL BochumVfL Bochum 0-1 1899 Hoffenheim |
| 23 | Sun 9 Mar | 71-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim |
| 24 | Fri 14 Mar | 70-1 v FC St PauliFC St Pauli 1-0 1899 Hoffenheim |
| 25 | Sat 29 Mar | 71-1 v FC Augsburg1899 Hoffenheim 1-1 FC Augsburg |
| 26 | Sat 5 Apr | 71-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim |
| 27 | Sat 12 Apr | 7 2-0 v Mainz 051899 Hoffenheim 2-0 Mainz 05 |
| 28 | Sat 19 Apr | 7 2-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim |
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