| 1 | Sat 24 Aug | 81-1 v 1 FC Union BerlinMainz 05 1-1 1 FC Union Berlin |
| 2 | Sun 15 Sep | 81-2 v Werder BremenMainz 05 1-2 Werder Bremen |
| 3 | Sat 28 Sep | 80-2 v 1 FC HeidenheimMainz 05 0-2 1 FC Heidenheim |
| 4 | Sat 5 Oct | 83-0 v FC St PauliFC St Pauli 0-3 Mainz 05 |
| 5 | Sat 19 Oct | 8 0-2 v RB LeipzigMainz 05 0-2 RB Leipzig |
| 6 | Fri 25 Oct | 81-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach |
| 7 | Sun 3 Nov | 80-0 v SC FreiburgSC Freiburg 0-0 Mainz 05 |
| 8 | Sat 9 Nov | 8 3-1 v Borussia DortmundMainz 05 3-1 Borussia Dortmund |
| 9 | Sun 24 Nov | 83-0 v Holstein KielHolstein Kiel 0-3 Mainz 05 |
| 10 | Sun 1 Dec | 82-0 v 1899 HoffenheimMainz 05 2-0 1899 Hoffenheim |
| 11 | Sun 8 Dec | 83-4 v VfL WolfsburgVfL Wolfsburg 4-3 Mainz 05 |
| 12 | Sat 14 Dec | 82-1 v Bayern MunichMainz 05 2-1 Bayern Munich |
| 13 | Sat 21 Dec | 83-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Mainz 05 |
| 14 | Sat 11 Jan | 82-0 v VfL BochumMainz 05 2-0 VfL Bochum |
| 15 | Tue 14 Jan | 80-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 Mainz 05 |
| 16 | Sun 19 Jan | 81-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 Mainz 05 |
| 17 | Sat 25 Jan | 82-0 v VfB StuttgartMainz 05 2-0 VfB Stuttgart |
| 18 | Fri 31 Jan | 80-1 v Werder BremenWerder Bremen 1-0 Mainz 05 |
| 19 | Sat 8 Feb | 80-0 v FC AugsburgMainz 05 0-0 FC Augsburg |
| 20 | Sun 16 Feb | 82-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 |
| 21 | Sat 22 Feb | 8 2-0 v FC St PauliMainz 05 2-0 FC St Pauli |
| 22 | Sat 1 Mar | 82-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 |
| 23 | Fri 7 Mar | 83-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 Mainz 05 |
| 24 | Sat 15 Mar | 82-2 v SC FreiburgMainz 05 2-2 SC Freiburg |
| 25 | Sun 30 Mar | 81-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 |
| 26 | Sat 5 Apr | 81-1 v Holstein KielMainz 05 1-1 Holstein Kiel |
| 27 | Sat 12 Apr | 8 0-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Mainz 05 |
| 28 | Sat 26 Apr | 80-3 v Bayern MunichBayern Munich 3-0 Mainz 05 |
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