| 1 | Sun 19 Oct | 53-0 v FC St PauliFC St Pauli 0-3 TSG Hoffenheim |
| 2 | Sat 25 Oct | 53-1 v 1 FC HeidenheimTSG Hoffenheim 3-1 1 FC Heidenheim |
| 3 | Sun 2 Nov | 53-2 v VfL WolfsburgVfL Wolfsburg 2-3 TSG Hoffenheim |
| 4 | Sat 8 Nov | 53-1 v RB LeipzigTSG Hoffenheim 3-1 RB Leipzig |
| 5 | Sat 29 Nov | 53-0 v FC AugsburgTSG Hoffenheim 3-0 FC Augsburg |
| 6 | Sat 13 Dec | 54-1 v Hamburger SVTSG Hoffenheim 4-1 Hamburger SV |
| 7 | Sat 20 Dec | 50-0 v VfB StuttgartVfB Stuttgart 0-0 TSG Hoffenheim |
| 8 | Wed 14 Jan | 55-1 v Borussia MönchengladbachTSG Hoffenheim 5-1 Borussia Mönchengladbach |
| 9 | Sat 24 Jan | 53-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 TSG Hoffenheim |
| 10 | Tue 27 Jan | 52-0 v Werder BremenWerder Bremen 0-2 TSG Hoffenheim |
| 11 | Sat 31 Jan | 53-1 v Union BerlinTSG Hoffenheim 3-1 Union Berlin |
| 12 | Sun 8 Feb | 51-5 v Bayern MunichBayern Munich 5-1 TSG Hoffenheim |
| 13 | Sat 14 Feb | 5 3-0 v SC FreiburgTSG Hoffenheim 3-0 SC Freiburg |
| 14 | Sat 21 Feb | 52-2 v 1 FC Köln1 FC Köln 2-2 TSG Hoffenheim |
| 15 | Sat 28 Feb | 5 0-1 v FC St PauliTSG Hoffenheim 0-1 FC St Pauli |
| 16 | Sat 7 Mar | 54-2 v 1 FC Heidenheim1 FC Heidenheim 2-4 TSG Hoffenheim |
| 17 | Sat 14 Mar | 51-1 v VfL WolfsburgTSG Hoffenheim 1-1 VfL Wolfsburg |
| 18 | Fri 20 Mar | 50-5 v RB LeipzigRB Leipzig 5-0 TSG Hoffenheim |
| 19 | Sat 4 Apr | 5 1-2 v Mainz 05TSG Hoffenheim 1-2 Mainz 05 |
| 20 | Fri 10 Apr | 52-2 v FC AugsburgFC Augsburg 2-2 TSG Hoffenheim |
| 21 | Sat 18 Apr | 52-1 v Borussia DortmundTSG Hoffenheim 2-1 Borussia Dortmund |
| 22 | Sat 25 Apr | 52-1 v Hamburger SVHamburger SV 1-2 TSG Hoffenheim |
| 23 | Sat 2 May | 5 3-3 v VfB StuttgartTSG Hoffenheim 3-3 VfB Stuttgart |
| 24 | Sat 9 May | 51-0 v Werder BremenTSG Hoffenheim 1-0 Werder Bremen |
| 25 | Sat 16 May | 5 0-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-0 TSG Hoffenheim |
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