| 1 | Fri 23 Aug | 13-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-3 Bayer 04 Leverkusen |
| 2 | Sat 14 Sep | 14-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen |
| 3 | Sun 22 Sep | 14-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg |
| 4 | Sat 28 Sep | 11-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen |
| 5 | Sat 5 Oct | 12-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel |
| 6 | Sat 19 Oct | 12-1 v Eintracht FrankfurtBayer 04 Leverkusen 2-1 Eintracht Frankfurt |
| 7 | Sat 26 Oct | 12-2 v Werder BremenWerder Bremen 2-2 Bayer 04 Leverkusen |
| 8 | Fri 1 Nov | 10-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart |
| 9 | Sat 9 Nov | 11-1 v VfL BochumVfL Bochum 1-1 Bayer 04 Leverkusen |
| 10 | Sat 23 Nov | 15-2 v 1 FC HeidenheimBayer 04 Leverkusen 5-2 1 FC Heidenheim |
| 11 | Sat 30 Nov | 12-1 v 1 FC Union Berlin1 FC Union Berlin 1-2 Bayer 04 Leverkusen |
| 12 | Sat 7 Dec | 12-1 v FC St PauliBayer 04 Leverkusen 2-1 FC St Pauli |
| 13 | Sat 14 Dec | 12-0 v FC AugsburgFC Augsburg 0-2 Bayer 04 Leverkusen |
| 14 | Sat 21 Dec | 15-1 v SC FreiburgBayer 04 Leverkusen 5-1 SC Freiburg |
| 15 | Fri 10 Jan | 13-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen |
| 16 | Sat 18 Jan | 13-1 v Borussia MönchengladbachBayer 04 Leverkusen 3-1 Borussia Mönchengladbach |
| 17 | Sat 25 Jan | 12-2 v RB LeipzigRB Leipzig 2-2 Bayer 04 Leverkusen |
| 18 | Sun 2 Feb | 13-1 v 1899 HoffenheimBayer 04 Leverkusen 3-1 1899 Hoffenheim |
| 19 | Sat 8 Feb | 10-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen |
| 20 | Sat 15 Feb | 10-0 v Bayern MunichBayer 04 Leverkusen 0-0 Bayern Munich |
| 21 | Sat 1 Mar | 14-1 v Eintracht FrankfurtEintracht Frankfurt 1-4 Bayer 04 Leverkusen |
| 22 | Sat 8 Mar | 10-2 v Werder BremenBayer 04 Leverkusen 0-2 Werder Bremen |
| 23 | Sun 16 Mar | 14-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen |
| 24 | Fri 28 Mar | 13-1 v VfL BochumBayer 04 Leverkusen 3-1 VfL Bochum |
| 25 | Sat 5 Apr | 11-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 Bayer 04 Leverkusen |
| 26 | Sat 12 Apr | 10-0 v 1 FC Union BerlinBayer 04 Leverkusen 0-0 1 FC Union Berlin |
| 27 | Sun 20 Apr | 1 1-1 v FC St PauliFC St Pauli 1-1 Bayer 04 Leverkusen |
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