| 1 | Sun 24 Aug | 60-1 v 1 FC KölnMainz 05 0-1 1 FC Köln |
| 2 | Sun 31 Aug | 61-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 |
| 3 | Sat 13 Sep | 60-1 v RB LeipzigMainz 05 0-1 RB Leipzig |
| 4 | Sat 20 Sep | 64-1 v FC AugsburgFC Augsburg 1-4 Mainz 05 |
| 5 | Sat 27 Sep | 60-2 v Borussia DortmundMainz 05 0-2 Borussia Dortmund |
| 6 | Sun 5 Oct | 60-4 v Hamburger SVHamburger SV 4-0 Mainz 05 |
| 7 | Sat 18 Oct | 63-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen |
| 8 | Sun 26 Oct | 61-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 |
| 9 | Sat 1 Nov | 61-1 v Werder BremenMainz 05 1-1 Werder Bremen |
| 10 | Sun 9 Nov | 60-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 |
| 11 | Fri 21 Nov | 61-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim |
| 12 | Sun 30 Nov | 60-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 |
| 13 | Fri 5 Dec | 60-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach |
| 14 | Sun 14 Dec | 62-2 v Bayern MunichBayern Munich 2-2 Mainz 05 |
| 15 | Sun 21 Dec | 6 0-0 v FC St PauliMainz 05 0-0 FC St Pauli |
| 16 | Sat 10 Jan | 62-2 v Union BerlinUnion Berlin 2-2 Mainz 05 |
| 17 | Tue 13 Jan | 62-1 v 1 FC HeidenheimMainz 05 2-1 1 FC Heidenheim |
| 18 | Sat 17 Jan | 61-2 v 1 FC Köln1 FC Köln 2-1 Mainz 05 |
| 19 | Sat 24 Jan | 63-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg |
| 20 | Sat 31 Jan | 62-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 |
| 21 | Sat 7 Feb | 62-0 v FC AugsburgMainz 05 2-0 FC Augsburg |
| 22 | Fri 13 Feb | 60-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 |
| 23 | Fri 20 Feb | 61-1 v Hamburger SVMainz 05 1-1 Hamburger SV |
| 24 | Sat 28 Feb | 61-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 |
| 25 | Sat 7 Mar | 62-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart |
| 26 | Sun 15 Mar | 62-0 v Werder BremenWerder Bremen 0-2 Mainz 05 |
| 27 | Sun 22 Mar | 62-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt |
| 28 | Sat 4 Apr | 62-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 |
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