| 1 | Sun 24 Aug | 70-1 v 1 FC KölnMainz 05 0-1 1 FC Köln |
| 2 | Sun 31 Aug | 71-1 v VfL WolfsburgVfL Wolfsburg 1-1 Mainz 05 |
| 3 | Sat 27 Sep | 70-2 v Borussia DortmundMainz 05 0-2 Borussia Dortmund |
| 4 | Sun 5 Oct | 7 0-4 v Hamburger SVHamburger SV 4-0 Mainz 05 |
| 5 | Sat 18 Oct | 73-4 v Bayer LeverkusenMainz 05 3-4 Bayer Leverkusen |
| 6 | Sun 26 Oct | 71-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 |
| 7 | Sat 1 Nov | 71-1 v Werder BremenMainz 05 1-1 Werder Bremen |
| 8 | Sun 9 Nov | 70-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 |
| 9 | Fri 21 Nov | 71-1 v TSG HoffenheimMainz 05 1-1 TSG Hoffenheim |
| 10 | Sun 30 Nov | 70-4 v SC FreiburgSC Freiburg 4-0 Mainz 05 |
| 11 | Fri 5 Dec | 70-1 v Borussia MönchengladbachMainz 05 0-1 Borussia Mönchengladbach |
| 12 | Sun 14 Dec | 72-2 v Bayern MunichBayern Munich 2-2 Mainz 05 |
| 13 | Sun 21 Dec | 70-0 v FC St PauliMainz 05 0-0 FC St Pauli |
| 14 | Sat 10 Jan | 72-2 v Union BerlinUnion Berlin 2-2 Mainz 05 |
| 15 | Tue 13 Jan | 72-1 v 1 FC HeidenheimMainz 05 2-1 1 FC Heidenheim |
| 16 | Sat 17 Jan | 7 1-2 v 1 FC Köln1 FC Köln 2-1 Mainz 05 |
| 17 | Sat 24 Jan | 73-1 v VfL WolfsburgMainz 05 3-1 VfL Wolfsburg |
| 18 | Sat 31 Jan | 72-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 |
| 19 | Sat 7 Feb | 72-0 v FC AugsburgMainz 05 2-0 FC Augsburg |
| 20 | Fri 13 Feb | 70-4 v Borussia DortmundBorussia Dortmund 4-0 Mainz 05 |
| 21 | Fri 20 Feb | 71-1 v Hamburger SVMainz 05 1-1 Hamburger SV |
| 22 | Sat 28 Feb | 71-1 v Bayer LeverkusenBayer Leverkusen 1-1 Mainz 05 |
| 23 | Sat 7 Mar | 72-2 v VfB StuttgartMainz 05 2-2 VfB Stuttgart |
| 24 | Sun 15 Mar | 7 2-0 v Werder BremenWerder Bremen 0-2 Mainz 05 |
| 25 | Sun 22 Mar | 72-1 v Eintracht FrankfurtMainz 05 2-1 Eintracht Frankfurt |
| 26 | Sat 4 Apr | 72-1 v TSG HoffenheimTSG Hoffenheim 1-2 Mainz 05 |
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