| 1 | Sat 23 Aug | 121-2 v TSG HoffenheimBayer Leverkusen 1-2 TSG Hoffenheim |
| 2 | Sat 30 Aug | 123-3 v Werder BremenWerder Bremen 3-3 Bayer Leverkusen |
| 3 | Fri 12 Sep | 123-1 v Eintracht FrankfurtBayer Leverkusen 3-1 Eintracht Frankfurt |
| 4 | Sun 21 Sep | 121-1 v Borussia MönchengladbachBayer Leverkusen 1-1 Borussia Mönchengladbach |
| 5 | Sat 27 Sep | 122-1 v FC St PauliFC St Pauli 1-2 Bayer Leverkusen |
| 6 | Sat 4 Oct | 122-0 v Union BerlinBayer Leverkusen 2-0 Union Berlin |
| 7 | Sat 18 Oct | 12 4-3 v Mainz 05Mainz 05 3-4 Bayer Leverkusen |
| 8 | Sun 26 Oct | 122-0 v SC FreiburgBayer Leverkusen 2-0 SC Freiburg |
| 9 | Sat 1 Nov | 120-3 v Bayern MunichBayern Munich 3-0 Bayer Leverkusen |
| 10 | Sat 8 Nov | 126-0 v 1 FC HeidenheimBayer Leverkusen 6-0 1 FC Heidenheim |
| 11 | Sat 22 Nov | 123-1 v VfL WolfsburgVfL Wolfsburg 1-3 Bayer Leverkusen |
| 12 | Sat 29 Nov | 12 1-2 v Borussia DortmundBayer Leverkusen 1-2 Borussia Dortmund |
| 13 | Sat 6 Dec | 12 0-2 v FC AugsburgFC Augsburg 2-0 Bayer Leverkusen |
| 14 | Sat 13 Dec | 122-0 v 1 FC KölnBayer Leverkusen 2-0 1 FC Köln |
| 15 | Sat 31 Jan | 12 3-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Bayer Leverkusen |
| 16 | Sat 7 Feb | 121-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 Bayer Leverkusen |
| 17 | Sat 14 Feb | 124-0 v FC St PauliBayer Leverkusen 4-0 FC St Pauli |
| 18 | Sat 21 Feb | 120-1 v Union BerlinUnion Berlin 1-0 Bayer Leverkusen |
| 19 | Sat 28 Feb | 12 1-1 v Mainz 05Bayer Leverkusen 1-1 Mainz 05 |
| 20 | Wed 4 Mar | 121-0 v Hamburger SVHamburger SV 0-1 Bayer Leverkusen |
| 21 | Sat 7 Mar | 123-3 v SC FreiburgSC Freiburg 3-3 Bayer Leverkusen |
| 22 | Sat 14 Mar | 12 1-1 v Bayern MunichBayer Leverkusen 1-1 Bayern Munich |
| 23 | Sat 4 Apr | 12 6-3 v VfL WolfsburgBayer Leverkusen 6-3 VfL Wolfsburg |
| 24 | Sat 11 Apr | 121-0 v Borussia DortmundBorussia Dortmund 0-1 Bayer Leverkusen |
| 25 | Sat 18 Apr | 121-2 v FC AugsburgBayer Leverkusen 1-2 FC Augsburg |
| 26 | Sat 25 Apr | 12 2-1 v 1 FC Köln1 FC Köln 1-2 Bayer Leverkusen |
| 27 | Sat 2 May | 124-1 v RB LeipzigBayer Leverkusen 4-1 RB Leipzig |
| 28 | Sat 9 May | 121-3 v VfB StuttgartVfB Stuttgart 3-1 Bayer Leverkusen |
| 29 | Sat 16 May | 121-1 v Hamburger SVBayer Leverkusen 1-1 Hamburger SV |
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